Researchers analyzing paired bone marrow and peripheral blood samples from healthy adults found that bone marrow serves as a major reservoir of varicella-zoster virus (VZV) reactive memory CD4⁺ T cells. It contains markedly higher absolute numbers of these cells and is enriched for polyfunctional memory T cells capable of producing multiple cytokines, a profile associated with stronger recall responses. These findings may help inform future strategies to better understand and prevent VZV reactivation.

Researchers at Gansu Agricultural University discovered that Alternaria alternata uses chitin deacetylases (CDAs) to modify its cell wall, effectively hiding from the host’s immune system to facilitate infection.

A research team has developed a Gaussian Splatting processing platform that supports end-to-end processing from data acquisition to multi-platform rendering. Their framework provides a solid foundation for the large-scale adoption and future research of Gaussian Splatting technology.

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and a leading cause of kidney failure in young adults. Many studies suggest the disease originates in the intestine, while direct evidence from human tissue has been scarce. By performing single-cell RNA sequencing on terminal ileum biopsies and blood samples from IgAN patients, researchers have constructed a high-resolution map of the gut immune microenvironment. They successfully pinpointed the specific immune cells driving the production of pathogenic IgA and identified B-cell maturation antigen (BCMA) as a critical regulator of this process. This discovery proposes BCMA as a promising upstream therapeutic target, potentially allowing doctors to treat IgAN at its mucosal source rather than just managing downstream kidney damage.