In a study published in Nature, University of Michigan researchers have identified that the balance between two proteins—STAT3 and STAT5—is important for making tumors vulnerable to immune checkpoint therapy, and targeting STAT3 degradation is a potential novel cancer immunotherapy strategy.

A new study from Scripps and the biotech Gero demonstrates that artificial intelligence can be used not just to accelerate drug discovery, but to fundamentally transform how it’s done—by targeting the full complexity of biological aging.

Researchers at the National Institutes of Health (NIH) have identified a series of changes in the architecture and cell composition of connective tissues of the breast, known as stromal tissue, that is associated with an increased risk of developing aggressive breast cancer among women with benign breast disease, and poorer rates of survival among women with invasive breast cancer. This process, which they call stromal disruption, could potentially be used as a biomarker to identify women with benign breast disease who are at high risk of developing aggressive breast cancers, as well as those with breast cancer who may be at increased risk of recurrence or death.

Evidence of a unique T cell may explain why urban children are more prone to allergies than rural children. Differences in the development of the gut microbiome may be an underlying cause.