In a study led by Naim Bautista of the University of Nebraska-Lincoln, highland deer mice and their lowland cousins ventured on a simulated seven-week ascent to 6,000 meters. By tracking how the mice responded to cold stress and progressively lower oxygen levels, the study tested whether deer mice have a generalized ability to acclimatize or whether some mice have evolved adaptations to local conditions. The highland mice were better able to regulate their body temperature, an indication that mice living at higher altitudes have evolved distinct ways to acclimatize to low oxygen conditions. 

Using the established cancer cell databases GDSC, CTRP and COSMIC, researchers developed a combined score of the 36 genes most linked to drug resistance. This polygenic score showed superior correlation with relative resistance to various anti-cancer drugs compared to existing polygenic score, and it predicted the expression of genes linked to breast cancer resistance against tamoxifen.