New research led by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London, in collaboration with an international partnership of researchers, has, for the first time, compared the genetics of people with binge eating versus those without any eating disorder. The paper also includes the largest ever genetic study of anorexia nervosa.  

For years, scientists have known that regular physical activity can help lower the risk of dementia. But new USC research suggests that it’s not only the amount but also the activity’s context — for work or for leisure — that makes a difference.

A meta-analysis of more than 4.2 million people has found that leisure-time exercise — activities such as walking, cycling, running, swimming or playing sports — is associated with a substantially lower risk of dementia. In contrast, physical activity performed as part of a job appears to be linked with a higher risk of developing the condition.

The findings, published in The Lancet Public Health, are the first to systematically examine whether the so-called “physical activity paradox” extends to dementia. This paradox, well documented in cardiovascular research, describes the surprising observation that physically demanding jobs do not provide the same health benefits as voluntary exercise — and may even increase disease risk.