Mechanisms of exosome biogenesis, engineering, and cellular interactions (IMAGE)
Caption
(A) Direct release of macromolecular cargoes into the cytoplasm via membrane fusion.(B) Generation of hybrid exosomes through the fusion of liposomes and natural exosomes.(C) Exosome biogenesis and secretion pathway within cells, illustrating the process of multivesicular body (MVB) formation from early endosomes via inward budding.(D) Interaction pathways between exosomes and recipient cells, including surface receptor signaling, endocytosis-mediated uptake and subsequent endosomal escape, as well as lysosomal degradation pathways.
Credit
Maosong Yang, Jiheng Wang, Chang Chen&Yang Liu
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CC BY-NC