Figure 4. Elucidation of the mechanism underlying autism onset through the CHD8 mutation and therapeutic applications. (IMAGE)

Kanazawa University

Figure 4. Elucidation of the mechanism underlying autism onset through the CHD8 mutation and therapeutic applications.

Caption

Figure 4. Elucidation of the mechanism underlying autism onset through the CHD8 mutation and therapeutic applications.
Next-generation sequencing analysis on cells harboring the CHD8 mutation at the midfetal stage revealed that abnormalities occurring when ventral progenitor cells differentiated into oligodendrocytes and inhibitory neurons were closely related to the onset of autistic-like behavior (upper panel). In addition, when CHD8 expression levels were restored at the midfetal stage in autism model mice, behavioral abnormalities were ameliorated (lower panel). These findings are expected to contribute to the elucidation of the pathophysiology of autism and to applications in its treatment.

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Adapted from Nitahara, K. et al., Nature Communications (2026), CC BY 4.0.

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