Figure 2. Behavioral abnormalities due to a CHD8 mutation at the midfetal stage. (IMAGE)

Kanazawa University

Figure 2. Behavioral abnormalities due to a CHD8 mutation at the midfetal stage.

Caption

Figure 2. Behavioral abnormalities due to a CHD8 mutation at the midfetal stage.
Mice were generated that develop a CHD8 mutation at a specific fetal stage and behavioral analysis was conducted after birth. As a result, it was revealed that mice with a CHD8 mutation induced at the midfetal stage (embryonic day 14.5) exhibited autistic-like behavior (abnormal social-interaction, left panel; anxiety-like behavior, right panel), while mice with a CHD8 mutation induced at the late fetal stage did not exhibit behavioral abnormalities.

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Adapted from Nitahara, K. et al., Nature Communications (2026), CC BY 4.0.

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