Figure 3. Abnormalities in inhibitory neural circuits arise in association with the CHD8 mutation. (IMAGE)

Kanazawa University

Figure 3. Abnormalities in inhibitory neural circuits arise in association with the CHD8 mutation.

Caption

Figure 3. Abnormalities in inhibitory neural circuits arise in association with the CHD8 mutation.
The team analyzed in vivo neural circuit function by expressing a light-sensitive gene in inhibitory neurons of the mouse medial prefrontal cortex and applying optical stimulation to that region (left panel). As a result, it was revealed that in CHD8-mutant mice, excitatory neurons were less susceptible to inhibition even when inhibitory neurons were stimulated (right panel).

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Adapted from Nitahara, K. et al., Nature Communications, (2026), CC BY 4.0.

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