Enriched transcription factor motifs determined using SCENIC analysis. (IMAGE)
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A: Heat map demonstrating the various activities of the cis module in each R-ISS stage. The x-axis represents each stage, and the y-axis indicates the manually divided CSI module. The colour of the CSI module changed from blue to yellow, indicating diverse activity from low to high in each stage. B: Identification of regulon modules based on the regulon matrix of MM patients and normal controls. Thirty-four orthologous TF regulons were grouped into four major modules. C: The network shows representative TF regulons in module 2 containing binding motifs, transcription factors and associated target genes. D and E: Regulon STAT1 and its putative target (LETM1) in the activity t-SNE map (D) and pseudotime trajectory (E). F and G: Regulon UQCRB and its putative target (PDIA6) in the activity t-SNE map (F) and pseudotime trajectory (G). H: Scatter plots showing the correlation of the gene expression levels of STAT1 and LETM1 and of UQCRB and PDIA6. I: KEGG analysis demonstrated the upregulated gene-enriched pathways in module 2.
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