Differential gene expression modules during malignant progression. (IMAGE)
Caption
A: t-SNE representation of nine subclusters (P1-P9) generated from sub-clustering plasma cells. B: Relative contributions of plasma cells from P1 to P9 in each stage, as shown by bar plots. C: The bar plots displayed relative contributions of plasma cells from P1 to P9 in each patient. D: Correlation matrix for plasma cells among nine subclusters across 11 subjects. Correlation coefficients are coloured blue to red to indicate low to high, respectively. E: Pseudotime trajectory of plasma cells from all samples. Each point corresponds to a single cell. F: Distribution plot of total plasma cells from two controls and nine patients (in different stages) according to the pseudotime trajectory. G: Distribution plot of nine subclusters of plasma cells on the pseudotime trajectory. H: Heat map showing the differentially expressed genes (rows) along the pseudotime (columns), clustered hierarchically into four modules. The representative gene functions and processes of each module are shown. The colour key from blue to red indicates relative expression levels from low to high. I: Expression dynamic fold changes of proliferation- and protein process-related genes in each subcluster according to pseudotime analysis. J: Violin plots representing heterogeneity in the expressions of LETM1, PDIA6 and WARS in plasma cells from control to stage III patients.
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