Intracortical microstimulation in brain–computer interfaces: Evoking perception and plasticity
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Oct-2026 12:16 ET (21-Oct-2026 16:16 GMT/UTC)
A review, published on September 11 in Cyborg and Bionic Systems by researchers at Tianjin University, summarizes recent advances in intracortical microstimulation (ICMS), a technique that uses tiny electrodes implanted in the brain to activate specific groups of neurons. The researchers discuss how ICMS has evolved from a tool for mapping brain function into a potential technology for sensory feedback, information delivery, closed-loop neuromodulation and biointegrated neural interfaces.
Brain–computer interfaces are increasingly being explored as a way to restore lost functions or provide new channels for communication between the nervous system and electronic devices. While much BCI research focuses on reading neural signals, ICMS provides the complementary ability to write information back into the brain.
“ICMS has emerged as a prominent invasive modality capable of activating intracortical neuronal populations with high precision,” the researchers write. The technology can potentially replace or supplement natural sensory inputs, probe
dysfunctional neural circuits and influence behavior.Multiphoton microscopy (MPM), with its excellent optical sectioning capability and deep tissue penetration, has become an important tool for neuroscience and biomedical imaging. However, efficient axial information acquisition remains a major challenge for high-speed volumetric imaging of dynamic biological processes. Recent advances in optical devices, light-field control, information encoding, and intelligent computing have expanded the approaches to axial imaging, ranging from single-point scanning and multifocal parallel imaging to continuous-beam coverage. This review summarizes these developments from the perspective of axial information acquisition, and further discusses light-field control for improving 3D imaging performance, providing an overview of the field and its future directions toward faster, deeper, and higher-quality volumetric MPM. Meanwhile, the focal control, temporal encoding, structured light fields, and computational reconstruction methods discussed in this review are highly transferable and can be extended to other laser-scanning microscopy modalities, such as coherent Raman and photoacoustic microscopy.
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