A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional therapeutic target. MYC is dysregulated in nearly 70% of human cancers, where it influences a vast network of biological processes including cell cycle control, metabolism, apoptosis, angiogenesis, and immune evasion. The article underscores how MYC not only drives aggressive tumor behavior but also contributes significantly to drug resistance, making it one of the most compelling yet complex targets in oncology.

The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies. As a SUMO E3 ligase, RANBP2 plays a pivotal role in post-translational modification, specifically SUMOylation, which is essential for regulating the cell cycle. Recent insights have highlighted the multifaceted involvement of RANBP2 in tumorigenesis, suggesting its potential as a therapeutic target for cancer treatment.

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer biology. As critical regulators of gene expression, RBPs control the formation and function of circRNAs, influencing various cancer-related processes such as tumor proliferation, metastasis, drug resistance, and immune evasion. This dynamic interplay has positioned the circRNA-RBP network as a promising target for developing innovative cancer therapies.