Cancer-fighting antibody drugs are designed to penetrate tumor cells and release a lethal payload deep within, but too often they don’t make it that far. A new study shows how this Trojan Horse strategy works better by exploiting calcium differences outside and inside cells. A research team led by Sophia Hober, professor at KTH Royal Institute of Technology, reported the development of a calcium activated delivery system they say could enable more precise treatment, with lower doses and less collateral damage to healthy tissue. 

A new study published in the journal Cancer Research led by University of Cincinnati Cancer Center researchers sheds new light on how pancreatic cancer cells develop treatment resistance and points to potential new combination therapies to make treatments more effective.