July Tip Sheet from Sylvester Comprehensive Cancer Center
Reports and Proceedings
Updates every hour. Last Updated: 18-Jul-2025 20:11 ET (19-Jul-2025 00:11 GMT/UTC)
New Haven, Conn. — Hypertensive disorders in pregnancy (HDP) — like chronic or gestational hypertension, preeclampsia, and eclampsia — are among the leading causes of maternal and infant death in the United States.
Between 2017 to 2019, 16% of all U.S. pregnancies were complicated by an HDP diagnosis, with much higher rates seen among non-Hispanic Black/African Americanand American Indian/Alaskan Native women. But HDPs don’t just affect women in the short term; these disorders can increase their long-term risk for heart disease, kidney disease, and stroke.
But there could be an opportunity to mitigate these longer-term health risks through breastfeeding, Yale researchers have found. In a new study, they discovered that an HDP diagnosis before or during pregnancy related to higher odds of never breastfeeding, or for those who initiated breastfeeding, higher probability of stopping. The findings suggest women with HDPs may benefit from targeted interventions that promote their exposure to the cardioprotective benefits of breastfeeding.
New research from Emory University reveals that even seemingly small lifestyle improvements decreased one’s risk of developing heart disease, and these decreases also translate to lower risk of subsequent conditions, such as cancer, dementia, type 2 diabetes, and eye, liver, and kidney diseases. The study also links heart health to vision, hearing, and dental health. The study analyzed more than 450 peer-reviewed studies, assessing the overall impact of implementing the American Heart Association’s Life’s Simple 7™ metrics, a series of preventative measures, which include: not smoking, healthy eating, regular physical activity, maintaining a healthy weight, and managing blood pressure, cholesterol, and blood sugar. Even a 1-point improvement on Life’s Simple 7™ scale, which ranges from 0-14 points, translates to critical health gains for the heart and other organs.
The tumor microenvironment (TME) is a critical factor in antitumor immunity and treatment outcome in cancer therapy. We have developed an analysis tool called the immuno-oncology biological research (IOBR) to investigate the TME and its role in antitumor immunity. Leveraging multi-omics data, IOBR facilitates comprehensive analysis of TME characteristics, immune interactions, and their impact on immunotherapy outcomes.
Scientists report a rare case of coexisting APC and KRAS mutations in a woman with familial adenomatous polyposis and prior endometrial cancer, highlighting a potential genetic synergy in multi-organ tumorigenesis.
A new study introduces an AI-integrated dynamic biomarker system that detects early disease tipping points and classifies thyroid cancer into actionable subtypes, paving the way for precision diagnosis and treatment.
This comprehensive review highlights the compositional and functional heterogeneity of intratumoral microbiota within the tumor microenvironment (TME), and their implications in tumorigenesis and cancer progression. The findings underscore the dual roles of these microbes in modulating immune responses and metabolic processes, offering new directions for cancer diagnostics and therapeutic interventions.