Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During their preparation for this battle, B cells transiently revert to a more flexible, or plastic, stem-cell-like state in the lymph nodes, according to a new preclinical study from Weill Cornell Medicine investigators. The results could help explain how many lymphomas develop from mature B cells rather than from stem cells, as many other cancers do, and guide researchers in developing better treatments.

Breast cancer relapse often begins long before it can be seen. 

Dlc1 deletion affects cardiac differentiation in mouse embryonic stem cells by activating the canonical Wnt pathway

Cardiomyocyte differentiation is an important event during heart development that involves the specification of cardiac lineage cells differentiated from mesendoderm to cardiac mesoderm. This specification is spatio-temporally regulated by multiple genes and signaling pathways.

Previous studies have shown that deleted in liver cancer 1 (DLC1), a tumor-suppressor gene, is involved in embryonic development, and its knockdown leads to the malformation of multiple organs, including abnormalities in cardiovascular system development and early fatalities.