Melanoma cells release small extracellular packages containing the protein nerve growth factor receptor, which primes nearby lymph nodes for tumor metastases, according to a new study by Weill Cornell Medicine investigators.
- Nature Cancer
MUSC Hollings Cancer Center researcher Sophie Paczesny, M.D., Ph.D., received a $628,188 grant from the National Cancer Institute (NCI) to use machine learning algorithms to improve graft-versus-host disease (GVHD) treatment strategies. Her studies will validate biomarker panels that may help doctors to determine each bone marrow transplant patient’s risk of developing chronic GVHD and adjust his or her immune suppression treatments accordingly.
- NIH/National Cancer Institute
New research shows that specific enzymes can remove lactic acid marks. This finding may increase our understanding of cancer medicine and how physical exercise, among other things, can affect human epigenetics.
A study by researchers at Mayo Clinic Cancer Center has found that patients with cancer who receive chemotherapy ― and some targeted therapies, such as CDK4/6 inhibitors and therapies targeted at B cells ― may mount an inadequate immune response to COVID-19 vaccination. The findings are published in Mayo Clinic Proceedings: Innovation, Quality & Outcomes.
- Mayo Clinic Proceedings Innovations Quality & Outcomes
MD Anderson and Yingli Pharma today announced a five-year strategic alliance to advance multiple oncology programs from preclinical discovery through clinical development.
Results of a large study led by UCLA Jonsson Comprehensive Cancer Center researchers could help guide treatment planning for patients with high-risk prostate cancer.
- JAMA Oncology
- , , , , Bershad Family Trust, DeSilva Family Trust,
For patients with advanced stage colon cancer or certain subtypes of lung cancer there are currently very limited treatment options available and rapid development of drug resistance poses a major challenge. In two experimental preclinical studies, scientists from the Experimental Pharmacology and Oncology (EPO) in Berlin-Buch together with their academic partners, have identified novel combination therapy approaches for these types of tumors. The data in these two studies provide strong evidence for further preclinical and clinical evaluation of these treatment approaches.
A new study based on data from a national cancer registry in Taiwan found evidence that lung cancer screening may be leading to overdiagnosis at the population level.
- JAMA Internal Medicine
Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. MGH investigators and colleagues have developed high-throughput microscopy and machine learning systems that can identify and classify DNA repair factors. The investigators have identified nine previously unknown factors involved in the process of cellular DNA repair.
- Cell Reports
- , , Nova Scotia Graduate Scholarship, , , , NIH/National Institute of Environmental Health Sciences, Natural Science and Engineering Research Council of Canada, European Union H-2020 Grant Program