Liver organoids, three-dimensional structures derived from stem cells or hepatic progenitors, have emerged as a transformative technology. Unlike traditional two-dimensional cultures or animal models, organoids faithfully recapitulate the complex architecture and functionality of native liver tissue. This review summarizes recent advancements in liver organoid technology, detailing their development, classification, and key applications.

New research from MUSC Hollings Cancer Center highlights a promising new approach to smoking cessation by targeting the brain’s executive control system. In a randomized clinical trial led by Hollings researcher Xingbao Li, M.D., noninvasive brain stimulation aimed at the dorsolateral prefrontal cortex helped participants reduce smoking and suppress cravings more effectively than other targeting approaches.

The findings suggest that strengthening brain regions involved in decision-making and self-control may help people to better manage the urge to smoke. The work adds to growing efforts at Hollings to expand evidence-based tobacco treatment options and better understand the brain mechanisms underlying addiction.