Engineering antibodies with a novel fusion protein
Peer-Reviewed Publication
Updates every hour. Last Updated: 2-May-2025 22:09 ET (3-May-2025 02:09 GMT/UTC)
Even with significant expansion in the global market for antibodies used in clinical care and research, scientists recognize that there is still untapped potential for finding new antibodies. Many proteins group together in what are called protein complexes to carry out biological functions. The traditional method of generating antibodies by immunizing animals struggles to make antibodies related to these protein complexes.
Scientists at Sanford Burnham Prebys and Eli Lilly and Company published findings March 5, 2025, in the Journal of Immunology demonstrating that fusing protein complexes together adds stability during immunization and enables antibody generation.New Haven, Conn. — Yale scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into “cold” tumors and flip on an immune response that has been turned off by cancer. The research, published in Science Signaling on March 25, offers new findings that could help improve therapies for glioblastoma and other aggressive cancers that are difficult to treat.
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