Until now, molecular-level DNA circuits have mainly been used for simple tasks, such as detecting the presence of cancer-related substances. However, these systems have faced a key limitation: once a reaction occurs, the circuits cannot be reused. Overcoming this challenge, the research team has developed a DNA-based molecular computer that operates at a much smaller scale than conventional semiconductor devices, enabling both computation and memory within the same system. This advancement opens up new possibilities for future computing technologies in bio and medical applications, including disease diagnosis.

Scientists have developed a strategy to boost the cancer-fighting power of natural killer (NK) cells, part of the immune system’s first line of defence. NK cells can detect and destroy cancer cells, but tumours often create a protective barrier that blocks them, allowing cancer to grow.

Researchers at McGill University’s Rosalind & Morris Goodman Cancer Institute, in collaboration with the Research Institute of the McGill University Health Centre, found that suppressing two specific proteins helps NK cells overcome this blockage, turning them into more potent cancer killers.

For the first time, Weill Cornell Medicine researchers have demonstrated that Hodgkin lymphoma cancer cells from patient samples are immune cells stuck in an “identity crisis.” Normally, a B cell matures into a plasma cell that produces antibodies to fight infection, but in this case, the cells are trapped partway through the transition. They switch off key B cell features but never fully mature into functional plasma cells, instead surviving as malignant Hodgkin lymphoma cells, also called Reed-Sternberg cells.

Researchers have discovered that a key protein, cFLIP, is essential for regulating programmed cell death in lymphoma cells. This discovery provides insights into the mechanisms of this cancer’s cell death evasion and could open up new therapeutic routes for patients who do not respond to therapies / publication in “Blood”

Researchers use advanced microscopy to visualise multiple biomolecules inside the nucleus of a cancer cell simultaneously at incredibly high resolution, providing one of the first detailed maps of nuclear organisation.