Repurposing a diabetes medication to prime CAR T cancer targets
Peer-Reviewed Publication
Updates every hour. Last Updated: 8-Nov-2025 16:11 ET (8-Nov-2025 21:11 GMT/UTC)
To improve treatment rates for these patients, UCSF researchers designed a CAR T cell therapy and combined it with an older class of diabetes drugs called thiazolidinediones, to enhance NECTIN4 expression and make tumor cells more susceptible to NECTIN4-CAR T therapy.
Researchers from the National University of Singapore and the National Cancer Centre Singapore have developed a hydrogel-based method to keep human lymph node tissue alive and functional outside the body for at least a week — significantly longer than existing approaches. By embedding tissue slices in a bioengineered gel that mimics the body’s natural environment, the system preserves the structure and immune functions of the lymph node, allowing scientists to observe real-time responses to cancer antigens and mRNA vaccines. The platform offers a more accurate and human-relevant alternative to preclinical models and could support the development of personalised immunotherapies and vaccines.
A University of Cambridge study of adult mammary gland development has revealed new genes involved in breastfeeding, and provided insights into how genetic changes may be associated with breastfeeding disorders and postpartum breast cancers.
OKLAHOMA CITY – University of Oklahoma Health Campus Ph.D. candidate Alex Arreola has earned a prestigious National Cancer Institute grant – one of only 15 awarded nationwide this year. He is the first trainee from OU Health Stephenson Cancer Center to receive the honor, which will support his doctoral and postdoctoral training in experimental oncology and pathology.