Delicate balancing act determines how many genome gateways form in cells
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Apr-2025 14:08 ET (29-Apr-2025 18:08 GMT/UTC)
As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus.
While the basic need for this shuttle service is constant, scientists have shown that cells dynamically adjust their amounts of NPCs like a retail store opening more or fewer checkout lines throughout the day. Scientists at Sanford Burnham Prebys published findings March 31, 2025, in Cell Reports revealing the results of screening the entire human genome to find factors influencing how many NPCs are assembled.A study appearing Monday, March 31 in Nature Physics presents a striking example of cooperative organization among cells as a potential force in the evolution of multicellular life. Based on the fluid dynamics of cooperative feeding by Stentor, a relatively giant unicellular organism, the study originated from the Marine Biological Laboratory (MBL), Woods Hole, Mass.