Highly educated people face steeper mental declines after stroke
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Updates every hour. Last Updated: 30-Apr-2025 02:08 ET (30-Apr-2025 06:08 GMT/UTC)
Opioid use disorder is associated with more than 350,000 deaths annually worldwide. Guided by the need for an increased understanding of critical neurobiological features of addiction, researchers have now found a unique molecular signature and genes in the orbitofrontal cortex associated with heroin-seeking behavior. A preclinical rodent model implicated a gene called Shisa7 as the key predictor. A new study in Biological Psychiatry, published by Elsevier, provides valuable insights into the neurobiological mechanisms underlying heroin addiction and may have implications for the development of innovative strategies to combat the ongoing opioid epidemic.
By watching the ebb and flow of the brain’s chemical signals, researchers are beginning to disentangle the molecular mechanisms underlying the intrinsic motivation to learn. In a new study of zebra finches published in Nature, researchers show that a hit a dopamine tells baby birds when their song practice is paying off. The findings suggest that dopamine acts like an internal “compass” to steer their learning when external incentives are absent.