In an effort to find new treatments for castrate-resistant prostate cancer, a TTUHSC research team led by Srinivas Nandana, Ph.D., and Manisha Tripathi, Ph.D., recently completed a study focused on uncovering the molecular and signaling mechanisms that drive the progression of advanced prostate cancer. Their study (“A TBX2-Driven Signaling Switch from Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer”), published by Oncogene, emphasized overcoming resistance to androgen receptor signaling inhibitors.

UChicago researchers develop a new technology to create a spatial map of gene expression for an entire organism.

A UCLA-led team has developed an advanced sensor platform that measures metabolites — key molecules involved in sustaining life through metabolism — inside the body in real time.

By mimicking natural metabolic pathways and using biological molecular toolkits, the sensors can track thousands of metabolites, far beyond the small set detectable by traditional sensors, while simplifying the technology development process.

This advance opens up new possibilities for diagnosing and managing disease, developing new drugs and unlocking deeper insights into how biological systems function.