High oxygen pressure based chemical avenue enables ultra-effectiveness in the growth of Eu-doped infinite layer nickelates showing RE-4f related quantum competition between high-Tc and reentrant superconductivity
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Oct-2026 16:17 ET (23-Oct-2026 20:17 GMT/UTC)
The researchers have developed a high-oxygen-pressure based chemical route to effectively grow infinite-layer nickelates spanning middle to heavy rare-earth compositions. The expanded materials platform reveals robust field-reentrant superconductivity at both edges of the superconducting dome: a magnetic field first suppresses zero resistance, then restores it within a finite field window. Rare-earth substitution can strengthen this reentrance or raise the onset superconducting temperature to 40.1 K, while optimized films carry 266 kA cm-2 at 2 K. High-field transport and muon-spin measurements link the competing states to rare-earth 4f magnetism, exchange-field compensation and enhanced magnetic correlations.
Scientists at Peking University have identified a mitochondrial protein that is essential for protecting motor neurons, offering new insight into how amyotrophic lateral sclerosis (ALS) may develop. The study, led by Dr. Xianhua Wang and Dr. Heping Cheng at the College of Future Technology, Peking University, shows that loss of the mitochondrial protein ROMO1 causes progressive damage to motor neurons and muscles in mice, closely resembling key features of human ALS. The findings were published online in Science Bulletin.
A new study in Science Bulletin reveals that maternal PAN2 protein is essential for early embryonic development by regulating mRNA poly(A) tail length. Using an oocyte-specific conditional knockout mouse model, researchers found that PAN2 deficiency causes embryos to arrest at the two-cell stage due to abnormal poly(A) tail elongation, maternal mRNA accumulation, and impaired zygotic genome activation. PAN2 recognizes substrates via the PAN3-PABPC1 complex, preferring tails lacking guanosine but enriched in uridine.
A research team led by Prof. Yi Sun at Zhejiang University, reported a unexpected finding that the combination of KrasG12D activation and genetic inactivation of UBE2M in the lung triggers the cGAS-STING-NF-κB signal to form a inflammatory tumor microenvironment (TME). Mechnistically, KrasG12D promotes the mitochondrial biogenesis, whereas UBE2M depletion inhibits Parkin neddylation and mitophagy, together causing the cytoplasmic release of damaged mitochondrial DNA. The STING antagonist H-151 rescues TME, indicating a causal role of the cGAS-STING signal. The study therefore demonstrates a unexpected role of UBE2M in prevention TME induced by Kras mutant.
A comprehensive in silico scan of human respiratory viruses identified 3CLpro cleavage motifs within influenza NP and PA. Experimental validation confirmed that 3CLpro-mediated cleavage triggers rapid protein degradation and cytoplasmic mislocalization. Consequently, both ectopic 3CLpro expression and SARS-CoV-2 replication effectively inhibit replication across diverse influenza virus strains, revealing a broad-spectrum antiviral mechanism.
Prolonged health uncertainty does not always stay in clinics or medical appointments. It can become part of everyday life, shaping work, relationships, identity, and the ability to imagine the future even when a person continues to function outwardly.
In a new analytic autoethnography, Mehmed Zahid Çögenli examined his own experience of living and working through prolonged health uncertainty. The analysis drew on approximately 1,150 lines of contemporaneous reflective writing, together with retrospective accounts and selected self-narrative documents, and used the concept of biographical disruption to understand how uncertainty entered ordinary life.
Four connected themes were identified: health uncertainty beyond the clinic; carrying competence under strain; silence, disclosure, and institutional vulnerability; and rebuilding a livable future. The study argues that continued productivity can conceal substantial invisible effort, and that prolonged uncertainty can become an occupational and relational burden even before medical clarity is reached.
The review was led by Prof. Shaorong Gao of Tongji University, in collaboration with researchers from multiple universities and research institutes across China. It examines how epigenetic mechanisms decide which genes are used, when they are used and how strongly they are expressed - from the earliest stages of development to aging, cancer and therapy.
Bringing together evidence from reproduction, embryonic development, stem-cell research, tissue maintenance, aging, cancer and clinical translation, the review assesses what these mechanisms may mean for reproductive medicine, regenerative medicine and precision treatment. It also distinguishes promising directions from interventions that still require stronger evidence on delivery, specificity and long-term safety.