Research review | Decoding the sepsis paradox: How emergency granulopoiesis shifts from defense to dysfunction
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Jun-2026 12:16 ET (29-Jun-2026 16:16 GMT/UTC)
In a comprehensive review published in Research, investigators from Zhongda Hospital, School of Medicine, Southeast University propose an integrative framework centered on EG to explain this shift from defense to dysfunction. The authors synthesize evidence across single-cell multi-omics, bone-marrow niche remodeling, and immunometabolic reprogramming. By integrating single-cell biology with bedside indicators, this work clarifies why a protective program becomes maladaptive and outlines practical avenues for biomarker-guided stratification.