Mitochondrial dysfunctions are associated with a variety of pathologies, and the onset and progression of disease are accompanied by alterations in extracellular biochemical and mechanical signals. Recent studies have demonstrated that physicochemical cues, especially mechanical cues, exert pivotal roles in the organization of mitochondrial network and their metabolic functions. Therefore, understanding the mechanisms that orchestrate mitochondrial morphology and function is essential for elucidating their roles in both health and disease. In this review, we initially elucidate the critical role of mitochondrial dynamics and function in disease progression, subsequently focusing on how cells perceive extracellular mechanical signals to modulate mitochondrial dynamics and function through mechanotransduction. Last, this review explores the potential future directions, stressing that understanding mitochondrial dysfunction is crucial for developing effective therapies to improve mitochondrial function and address related diseases.

This work proposes Ves-GAN, a novel denoising framework that meets the challenges of data acquisition and assumptions about noise characteristics. By providing robust noise reduction while maintaining vascular integrity, Ves-GAN facilitates more reliable clinical evaluations and improves the overall quality of cardiovascular diagnosis.

Quantum computing is widely believed to be a revolutionary new technology. In fact, it is a double-edged sword. If efficient quantum computers can be manufactured in near future, many of the current cryptosystems will be in danger and post-quantum cryptography will be crucial to the security of our communications.

Atherosclerosis is driven by plaque buildup and foam cell formation in arteries. Researchers developed a luteolin-based nanomedicine designed for precise delivery and traceless release under plaque conditions. The therapy enhances lipid efflux in foam cells, reducing plaque size and improving stability. Preclinical studies show this approach could offer a targeted and effective strategy for treating atherosclerosis and lowering the risk of serious cardiovascular events.

Recent experimental findings from the research team led by Prof. Jianbo Hu at the Institute of Fluid Physics, China Academy of Engineering Physics (CAEP), revealed partial dislocation-mediated plastic flow in shock-loaded single-crystal aluminum.​​ The experiment was conducted at the PF-AR NW14A beamline of the High Energy Accelerator Research Organization (KEK). Utilizing laser ablation to generate shock waves and employing ultra-bright, ultra-short X-ray pulses from synchrotron radiation, the team captured in situ Laue diffraction patterns of single-crystal Al during dynamic loading. ​​This work provides the first experimental evidence of partial-dislocation-dominated plastic flow in shock-compressed single-crystal Al​​, enabling analysis of the distinct deformation mechanisms between quasi-static and dynamic loading in aluminum—a high stacking fault energy metal. ​​These findings offer new insights into the plastic deformation of aluminum under high strain rates and establish novel theoretical and experimental foundations for multi-scale research on material performance under extreme conditions.​Recent experimental findings from the research team led by Prof. Jianbo Hu at the Institute of Fluid Physics, China Academy of Engineering Physics (CAEP), revealed partial dislocation-mediated plastic flow in shock-loaded single-crystal aluminum.​​ The experiment was conducted at the PF-AR NW14A beamline of the High Energy Accelerator Research Organization (KEK). Utilizing laser ablation to generate shock waves and employing ultra-bright, ultra-short X-ray pulses from synchrotron radiation, the team captured in situ Laue diffraction patterns of single-crystal Al during dynamic loading. ​​This work provides the first experimental evidence of partial-dislocation-dominated plastic flow in shock-compressed single-crystal Al​​, enabling analysis of the distinct deformation mechanisms between quasi-static and dynamic loading in aluminum—a high stacking fault energy metal. ​​These findings offer new insights into the plastic deformation of aluminum under high strain rates and establish novel theoretical and experimental foundations for multi-scale research on material performance under extreme conditions.​