EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 15-Dec-2025 07:11 ET (15-Dec-2025 12:11 GMT/UTC)

Indoor tanning makes youthful skin much older on a genetic level

University of California - San Francisco
Peer-Reviewed Publication

Tanning bed users are known to have a higher risk of skin cancer, but for the first time researchers have found that young indoor tanners undergo genetic changes that can lead to more mutations in their skin cells than people twice their age.

Journal: Science Advances
Funder: NIH/National Cancer Institute, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, U.S. Department of Defense, Melanoma Research Alliance

Germline pathogenic variants among women without a history of breast cancer

JAMA Network
Peer-Reviewed Publication

About The Study: In this secondary analysis of the WISDOM trial, a randomized clinical trial that enrolled women without breast cancer ages 40 to 74, criteria-independent genetic testing in a pragmatic trial identified a substantial number of women with clinically actionable results, many of whom would not have qualified for genetic testing under current guidelines. These findings support broader access to genetic testing as part of personalized breast cancer risk assessment.

Journal: JAMA Internal Medicine

Innovating to serve the world: UCLA researchers elected to National Academy of Inventors

University of California - Los Angeles Health Sciences
Grant and Award Announcement

Maher El-Kady, whose work on energy solutions promises a cleaner, more sustainable and more accessible energy future, and Dr. Dennis Slamon, whose groundbreaking innovations in breast cancer treatment have benefited millions around the globe, today join more than 30 other UCLA researchers who have received the honor — the highest professional distinction awarded to inventors.

Risk-based vs annual breast cancer screening / the WISDOM randomized clinical trial

JAMA Network
Peer-Reviewed Publication

About The Study: In a randomized clinical trial, researchers found risk-based breast cancer screening was as safe as annual screening for detecting advanced cancers but did not reduce breast biopsy rates. Corresponding author Laura J. Esserman, MD, MBA, of the University of California, San Francisco, will present the study at the San Antonio Breast Cancer Symposium.

Journal: JAMA

Early relapse predicts poor outcomes in aggressive blood cancer

Mass General Brigham
Peer-Reviewed Publication

Mature nodal T-cell lymphoma is a type of rare and aggressive blood cancer. Limited data make it difficult to identify high-risk patients or tailor treatment strategies, so most patients receive similar care despite differences in disease characteristics and outcomes. A new study led by investigators from PETAL Consortium at the Mass General Brigham Cancer Institute found that among patients who achieved a complete remission after initial chemotherapy treatment, survival was worse for those whose disease relapsed within 12 months of initial treatment, suggesting that alternative strategies are needed to benefit these patients. The results are published in Blood.

Journal: Blood
Funder: Daiichi Sankyo Company, Secura Bio, Inc, Acrotech Biopharma, Kyowa Kirin, Center for Lymphoma Research Funds, National Cancer Institute K08 Career Development Award, MGH Lymphoma Research Funds, Reid Family Fund for Lymphoma Research, Translational Orphan Blood Cancer Research Center at UVA by the Scarlet Foundation, NIH/National Cancer Institute
Meeting: 67th American Society of Hematology (ASH) Annual Meeting and Exposition

Study explores why some drug therapies are ineffective for brain tumor patients

University of Plymouth
Grant and Award Announcement

New research taking place at the University of Plymouth's Brain Tumour Research Centre of Excellence, and supported by the Children’s Tumor Foundation, will trial combinations of drugs to try and find the first effective non-surgical treatments for patients with neurofibromatosis type 2 (NF2)

Funder: Children's Tumor Foundation

Large-scale study provides real-world data on rare side effect of cancer immunotherapy

Mass General Brigham
Peer-Reviewed Publication

Researchers led by investigators at Mass General Brigham have published valuable information about a rare but serious complication of anti-cancer immunotherapy, providing the first large-scale description of its risk factors and clinical course, and underscoring the importance of early diagnosis and treatment. The findings are published in Blood and simultaneously presented at the American Society of Hematology Annual Meeting.

Journal: Blood
Meeting: 67th American Society of Hematology (ASH) Annual Meeting and Exposition

Engineering oncolytic bacteria as precision cancer therapeutics: Design principles, therapeutic strategies, and translational perspectives

Higher Education Press
Peer-Reviewed Publication

Engineered oncolytic bacteria have emerged as a promising therapeutic platform for precision cancer treatment, offering tumor-specific colonization, immune activation, and controllable therapeutic delivery. This review summarizes recent advances in the design and application of synthetic biological strategies that enhance bacterial precision, safety, and efficacy in tumor therapy. These strategies are categorized into three major regulatory modes: exogenous input–responsive gene circuits, autonomous bacterial signal–responsive gene circuits, and tumor microenvironment-responsive gene circuits.

Journal: Protein & Cell

Pleural cavity macrophages promote lung tumor establishment through tissue invasion

Higher Education Press
Peer-Reviewed Publication

Preclinical studies indicate that cavity-resident macrophages in the peritoneal and pleural spaces contribute to immunosuppression and cancer progression. While these macrophages typically accumulate on organ surfaces rather than deeply infiltrating into tissues, their behavior and function in tumors remains unclear.

Journal: Protein & Cell

Mobile health tool may improve quality of life for adolescent and young adult breast cancer survivors

American Association for Cancer Research
Reports and Proceedings

A mobile health (mHealth) intervention for adolescent and young adult breast cancer survivors that offered tailored support by monitoring electronic patient-reported outcomes (ePROs) significantly improved quality of life and symptoms related to vaginal and arm problems, according to results from a randomized clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

Meeting: San Antonio Breast Cancer Symposium (SABCS)

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