A Science China Life Sciences study reveals that glioblastoma (GBM) hijacks oxygen-deprived conditions by forming nuclear “stress droplets” that activate the enzyme PRMT2, fueling tumor survival independently of the classic HIF pathway. Blocking PRMT2’s phosphorylation with the orphan drug TG02 dismantles these droplets and—when combined with standard chemotherapy temozolomide—restores drug sensitivity, dramatically shrinking tumors and extending survival in resistant mouse models.

A study published today in Nature Communications describes how lymphatic endothelial cells assist in generating robust immune memory, offering new insights into how the immune system functions.

Specifically, the researchers found there is a particular genetic program within the lymphatic endothelial cells that enables storage and archival of portions of an immunization or pathogen (antigens) for future use.

The research is among the first to outline that there’s a genetic “transcriptional” program within lymphatic endothelial cells that impact the immune response and could be manipulated.

The study was led by researchers from the University of Colorado Anschutz, with experts in medicine, immunology and microbiology and biochemistry and molecular genetics.