EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 23-Dec-2025 20:11 ET (24-Dec-2025 01:11 GMT/UTC)

Zebrafish models offer fast and effective guidance for personalized therapies for kids with high-risk cancer

Children's Hospital of Eastern Ontario Research Institute
Peer-Reviewed Publication

New research reveals that a small tropical fish can help guide personalized medicine and tailored therapies for some of the most challenging, high-risk pediatric cancer cases. Molecular profiling has transformed cancer care, but 30% of high-risk pediatric cancers do not have actionable therapeutic targets, limiting personalized treatment options and negatively affecting survival outcomes

Journal: Cancer Research Communications
Funder: Cancer Institute, National Health and Medical Research Council, Children's Hospital of Eastern Ontario Foundation, CHAMO

Loss of Trp53 gene promotes tumor growth and immune suppression in ovarian cancer

Impact Journals LLC
Peer-Reviewed Publication

BUFFALO, NY – September 24, 2025 – A new research paper was published in Volume 16 of Oncotarget on September 22, 2025, titled “Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma.”

Journal: Oncotarget

No GPS in the head: How the brain flexibly switches between internal maps

German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)
Peer-Reviewed Publication

Since their discovery in 2004, the grid cells in the brain, which are important for our orientation, have been regarded as a kind of “GPS in the head.” However, scientists at the German Cancer Research Center (DKFZ) and Heidelberg University Hospital have now shown that grid cells work much more flexibly than previously assumed. In experiments with mice, the researchers found that the cells adapt their activity to different reference points depending on the situation. Instead of providing a rigid global grid, they switch dynamically between different reference frames.

Journal: Nature Neuroscience

Weight loss treatments for people with diabetes and obesity could lower the risk of obesity-related cancers

University of Leicester
Peer-Reviewed Publication

Weight loss treatments, including medication and surgical procedures, may help lower the risk of obesity-related cancers in people with obesity and type 2 diabetes, a new study shows.

Journal: Diabetes Obesity and Metabolism
Funder: NIHR Leicester Biomedical Research Centre

Fatty acids feed cancer-promoting bacteria: How chronic cellular stress alters the gut microbiome

Technical University of Munich (TUM)
Peer-Reviewed Publication

It is well established that gut microbiome composition plays a pivotal role in human health – yet the precise connections are still not fully elucidated. Researchers at the Technical University of Munich (TUM) have moved a step closer to understanding these complex interactions: they have identified a cellular mechanism that alters the gut microbiome in a way that promotes cancer. An analysis of patient data shows that the findings also apply to humans.

Journal: Nature Metabolism
Funder: Deutsche Forschungsgemeinschaft

Distribution of fat could influence cancer risk, study suggests

University of Bristol
Peer-Reviewed Publication

How fat is distributed in people’s bodies could make a difference to their risk of certain cancers, according to new research led by the University of Bristol. The international study is published in the Journal of the National Cancer Institute (JNCI) today [24 September].

Journal: JNCI Journal of the National Cancer Institute
Funder: World Cancer Research Fund, Cancer Research UK, Medical Research Council

Sylvester to participate in $16M national study on artificial intelligence in breast cancer screening

University of Miami Miller School of Medicine
Grant and Award Announcement

Sylvester Comprehensive Cancer Center will co-lead a new $16M, multi-institutional clinical trial to evaluate whether artificial intelligence can help support radiologists in interpreting mammograms more accurately, with the goal of improving breast cancer screening and reducing unnecessary callbacks and anxiety for patients.

Funder: Patient-Centered Outcomes Research Institute

UCLA to lead $16 million national study on artificial intelligence in breast cancer screening

University of California - Los Angeles Health Sciences
Grant and Award Announcement

UCLA and UC Davis will co-lead a newly funded, multi-institutional clinical trial to evaluate whether artificial intelligence (AI) can help support radiologists in interpreting mammograms more accurately, with the goal of improving breast cancer screening and reducing unnecessary callbacks and anxiety for patients.

Not all ALK fusions act the same: Variants influence treatment success in lung cancer

German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)
Peer-Reviewed Publication

About five percent of lung adenocarcinomas, one of the most common forms of lung cancer, are driven by a faulty fusion of two genes, EML4 and ALK. This fusion results in different variants, and until now, clinicians have treated all patients with these fusions the same way. However, new research led by scientists from the German Cancer Research Center (DKFZ) and Stanford University shows that not all fusion variants behave alike. The team discovered that EML4-ALK variant V3 drives more aggressive tumors than the V1 variant and responds less effectively to targeted drugs. The findings, may pave the way for more personalized therapies.

Journal: Cancer Discovery

Molecular breast imaging may benefit women with dense breasts

Radiological Society of North America
Peer-Reviewed Publication

Screening women with dense breasts with both molecular breast imaging and digital breast tomosynthesis (DBT) increased overall invasive cancer detection while modestly increasing the recall rate compared with screening only with DBT, according to a new study.

Journal: Radiology