Using terbium against lymphoma
Peer-Reviewed Publication
Updates every hour. Last Updated: 13-Sep-2025 22:11 ET (14-Sep-2025 02:11 GMT/UTC)
Scientists have identified why some patients don’t respond to immune checkpoint blockade (ICB) therapy for solid cancer tumours and developed a new combination therapy. Identifying this mechanism is important as it identifies patients who will not respond to single agent ICB treatment such as anti-PD1 antibody therapy, but are most likely to benefit from the new combination therapy that they have identified, anti-CD30. By simply adding anti-CD30 for these patients, they believe they can improve response to cancer and avoid costly delays.
When cancer spreads from a primary tumor to new sites throughout the body, it undergoes changes that increase its genetic complexity.
A new study from researchers at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center (MSK) provides fresh insights about how cancers evolve when they metastasize — insights that could aid in developing strategies to improve the effectiveness of treatment.
The Alliance for Clinical Trials in Oncology announced today results from ATOMIC (A021502), a phase III trial evaluating standard chemotherapy alone or combined with atezolizumab (Tecentriq®) in treating patients who have surgically resected stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair (dMMR). The study, sponsored by the National Cancer Institute (NCI) and conducted in partnership with Genentech, a member of the Roche Group, met its primary endpoint, demonstrating a statistically significant improvement in disease-free survival (DFS) with the addition of atezolizumab, an anti-PD-L1 monoclonal antibody, to standard adjuvant FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin). The data are being presented today at 1:05 pm CDT/2:05 pm ET during the Plenary Session at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting (LBA1) by Alliance Study Chair Frank Sinicrope, MD.