Saitama University researchers discover that a natural peptide aptamer switches between two target proteins depending on metal ions
Peer-Reviewed Publication
Updates every hour. Last Updated: 27-Oct-2026 22:16 ET (28-Oct-2026 02:16 GMT/UTC)
A research team at Saitama University has discovered that calmodulin-binding peptide (CBP) can switch between two distinct target proteins depending on the surrounding metal-ion environment. Specifically, CBP binds calmodulin in the presence of calcium ions but recognizes human midkine in the presence of sodium ions. By combining surface plasmon resonance experiments with AlphaFold 3 structural prediction, the team uncovered a previously unrecognized mechanism of ion-dependent molecular recognition by a naturally occurring peptide. This finding opens new possibilities for peptide-based molecular recognition, diagnostic technologies, and drug discovery.
Sylvester Comprehensive Cancer Center’s July tip sheet contains several story ideas, including cancer researchers training as firefighters, new pancreatic cancer research, sex-specific immune differences in GBM, and a sarcoma expert who is exploring AI to develop better predictive models for bone cancer.
Researchers at The University of Texas MD Anderson Cancer Center have discovered a new way in which T cells attack acute myeloid leukemia (AML) cells, which may help explain why AML is particularly sensitive to immune-based treatments and could guide the development of future cancer immunotherapies.
New data on breastfeeding initiation across the U.S. reveal broad geographic patterns as well as local factors that can inform targeted public health interventions. The study by Tony Grubesic from the University of California Riverside and colleagues was published July 15, 2026, in the open-access journal PLOS Global Public Health.