Molecular docking of resveratrol with ovarian cancer-associated proteins and its therapeutic benefits
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Jun-2026 19:15 ET (22-Jun-2026 23:15 GMT/UTC)
Paired Box 3 (PAX3) is a protein that plays a critical role in the formation of tissues and organs during embryonic development and can positively (and less frequently, negatively) regulate gene expression. While progress has been made to advance our understanding of this critical and multi-faceted protein, there is still much that is unknown about the mechanisms by which PAX3 controls such a wide array of key cellular functions.
In a new review in the journal Biomolecules, researchers report that PAX3 is essential for the development of nerves, muscles, and melanocytes in embryos, and also plays a role in maintaining adult tissues in stem cells. Additionally, in some cancers, such as some muscle tumors and melanoma, researchers found that PAX3 is present in abnormally high levels and promote tumor progression.
An international research team from Bielefeld University and the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has uncovered a previously unknown regulatory mechanism in human cells. For the first time, they demonstrate how a key molecular switch regulates the cell’s “recycling centers.” The findings, published in the prestigious journal Nature Communications, provide important insights into the understanding of cancer and neurodegenerative diseases.
A significant step toward the potential prevention of stomach cancer: Researchers at the Technical University of Munich (TUM) have increased the effectiveness of a standard antibiotic by a factor of 60 through targeted chemical modifications. In laboratory and animal studies, the new drug candidate successfully combats the bacterium Helicobacter pylori, which is closely associated with the development of stomach cancer. The study findings were published in the journal Nature Microbiology.
Researchers from City University of Hong Kong, the Chinese Academy of Sciences, and the Massachusetts Institute of Technology have developed an artificial intelligence-driven workflow called AAPSI (AI-Accelerated PhotoSensitizer Innovation) that integrates expert knowledge, scaffold-based molecule generation, and Bayesian optimization to accelerate the discovery of novel photosensitizers for photodynamic therapy (PDT). Through this workflow, the team generated 6,148 candidate molecules and experimentally validated a hypocrellin-based compound, HB4Ph, which achieves a singlet oxygen quantum yield (ϕΔ) of 0.85 and absorption maxima (λmax) of 645 nm — outperforming all clinical and trial-stage photosensitizers. The work is published in AI for Science .
Northwestern Medicine scientists have discovered that specialized immune cells within the glioblastoma tumor metabolize fructose to suppress immune responses and promote tumor growth, reports a study published on March 17 in the Proceedings of the National Academy of Sciences.
The study, the first to identify this sugar pathway as a driver of immune suppression in brain tumors, suggests that blocking fructose metabolism in the specialized cells may improve immunotherapy response and patient outcomes.
Every year, millions of people are diagnosed with cancer globally; however, current treatments are limited by disease complexity. A study published March 17th in the open-access journal in PLOS Biology by Tianyu Jiang at Shandong University, Qingdao, China and colleagues suggests that Escherichia coli Nissle 1917 (EcN) may be engineered with anticancer agents to treat cancerous tumors in mice.