Researchers at Moffitt Cancer Center have identified distinct spatial tumor–immune ecosystems that predict whether patients with advanced non–small cell lung cancer will benefit from immunotherapy. The findings, published in Cancer Research, show that analyzing how tumor and immune cells are organized and interact within the tumor microenvironment may predict disease progression more accurately than PD-L1 status alone. The paper was featured on the cover of the publicationand is also part of its Data Science special series. 

Researchers from the Johns Hopkins Kimmel Cancer Center and The Johns Hopkins University have created a novel database structure that allows investigators anywhere to more easily study multiple types of cancer data — including laboratory results, genetic sequencing and imaging data — in one setting.

Ludwig Cancer Research is proud to announce that Director of the Oxford Branch of the Ludwig Institute for Cancer Research Xin Lu and the Institute’s CEO and Scientific Director Chi Van Dang are co-recipients of a 2026 Cancer Grand Challenges award as members of the ATLAS (for Antibody Tracking for Long-term Avoidance and Surveillance) team.

The continuous movement of the vocal cords weakens and eventually stops as laryngeal cancer progresses. Researchers have, for the first time, discovered that restoring cellular vibration reduces the aggressiveness of advanced vocal cord cancer. When cancer cells were exposed to sound-wave vibration, a protein that promotes cancer growth and severity decreased.

With up to $25 million from Cancer Grand Challenges, an international team led by UC San Diego professor Ludmil Alexandrov, will unlock the secrets of DNA's "fingerprints."

Cancer cell-derived small extracellular vesicles (sEVs) can travel from distant tumors through the bloodstream and kidneys and be excreted into urine, as reported by researchers at Science Tokyo. Using sophisticated molecular tagging systems in mouse models of brain, lung, and pancreatic cancer, the researchers directly traced sEVs from tumors to urine. They also revealed that the kidney’s glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.