Scientists gain insight into RNA-editing protein that could lead to improved treatment for cancer, autoimmune diseases
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-Jul-2025 19:10 ET (11-Jul-2025 23:10 GMT/UTC)
Researchers have identified a previously unknown bacterial protein, the structure of which is being used in the design of protein nanoparticles for the targeted delivery of anticancer drugs to tumors.
Pancreatic cancer is one of the leading causes of cancer-related mortality, with pancreatic ductal adenocarcinoma (PDAC) accounting for 90% of all cases. As most PDAC cases are diagnosed at advanced stages, surgical interventions are ineffective, and consequently, lymph node metastasis manifests in 70% of PDAC patients. Moreover, since the number of genetic mutations giving rise to PDAC are low, there are fewer available targeted therapeutic modalities. Analysis of gene expression at the single-cell level may help understand the tumor dynamics of PDAC.
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide. Despite the success of immune checkpoint blockade therapies in various solid tumors, immunotherapy for CRC remains a challenge. Hence, there is a critical need to understand the complex tumor microenvironment (TME) of CRC and identify potential targets to develop new immunotherapies.
In the continuing evolution of personalized medicine, a new Yale study has found evidence to support the value of a tool that measures the presence of cancer-derived molecules in the blood of patients with lung cancer years after their treatment.
This tool is a type of molecular residual disease (MRD)detector, which is used after patients have completed their primary treatment in order to monitor their cancer status. Researchers say it could inform clinical intervention, including whether to restart or intensify treatment.
Newborns with congenital heart defects may have a higher risk of developing childhood cancer compared to children born without a heart abnormality.