Breast cancer progression is increasingly recognized as being shaped not only by protein-coding oncogenes but also by long non-coding RNAs (lncRNAs) that regulate gene expression across multiple cellular compartments. While many lncRNAs have been linked to tumor growth, how their subcellular localization contributes to coordinated oncogenic signaling remains incompletely understood.

A novel study using a mouse model has found that the absence of the angiopoietin-like 4 (ANGPTL4) protein during development triggers a long-lasting reprogramming of the immune system that protects against intestinal inflammation. The findings from the study in The American Journal of Pathology, published by Elsevier, may have important implications for identifying molecular or cellular signatures that predict disease susceptibility, and for developing therapeutic strategies that enhance protective immune programs in inflammatory bowel disease and inflammation-driven colorectal cancer.

Data was used from Veterans Affairs health system

Patients who were retreated with docetaxel had longer overall survival compared with those who switched to cabazitaxel

Findings were published in JAMA Network Open

University of Missouri researchers have released the world’s largest collection of protein models with quality assessment — a groundbreaking new resource that could accelerate drug development for diseases such as Alzheimer’s and cancer. The database, called PSBench, includes 1.4 million annotated protein structure models, all verified by independent experts. It gives scientists the reliable information they need to build more accurate artificial intelligence (AI) systems for assessing the quality of protein structure models, which is critical for developing future medical treatments.