Proteins are conventionally trafficked and secreted extracellularly via the endoplasmic reticulum-Golgi pathway. Some proteins that bypass this system and use unconventional mechanisms to exit the cell have been implicated in neurodegenerative diseases, inflammation, and cancer. Researchers from Japan have elucidated a novel role of autophagy mediated by the formation of “secretory autolysosomes” in the release of PARK7—a protein associated with Parkinson’s disease (PD). Their findings uncover potential pathogenic mechanisms, early biomarkers, and therapeutic targets.

As part of ARPA-H's landmark ADAPT initiative, UC San Diego researchers will develop cutting-edge tools for precision oncology that act as "digital tumors," predicting treatment response and responding to changes in disease course.

City of Hope will present novel cancer treatment approaches and combinations, leading-edge targeted therapies, and supportive care interventions at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting taking place May 30 to June 3 in Chicago and online.

Four Weill Cornell Medicine investigators received the Ritu Banga Healthcare Disparities Research Awards, recognizing innovative research that will help close care gaps in clinical settings.

U of A Cancer Center researchers hope to image nerve endings and create objective, quantitative biomarkers for CIPN, leading to better treatment and prevention opportunities.

Women who choose to stop treatment during pregnancy and breastfeeding are putting their health at risk, and have to weigh their desire to have children and breastfeed against a risk that we know very little about. In two ongoing clinical trials, researchers establish a new standard for human lactation studies that includes sampling of breast milk and plasma from both mothers and breastfed infants. The new protocol is described in a new article in BMJ Open.