Study reveals how high blood pressure increases susceptibility to heart damage caused by a key cancer treatment
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Jun-2026 03:16 ET (22-Jun-2026 07:16 GMT/UTC)
Pancreatic cancer is difficult to treat and has a poor prognosis, but a new study from Tokyo University of Science highlights a gene that could change this outlook. By analyzing large cancer datasets, researchers found that the gene CTDNEP1 is significantly reduced in pancreatic tumors and associated with early disease progression and poorer survival. The findings suggest that CTDNEP1 may act as a tumor suppressor, offering promising opportunities for early detection and future treatment strategies.
This review explains how the metabolite itaconate actively shapes immunity by regulating inflammation, cellular metabolism, oxidative stress, and programmed cell death. The researchers show how two key modifications—S-itaconation and K-itaconation—directly alter protein function and influence pathways such as interferon signaling, glycolysis, pyroptosis, and ferroptosis. The study highlights how itaconate affects infection control, tumor behavior, and immune balance, and outlines its therapeutic promise in sepsis, colitis, neurodegeneration, autoimmunity, and cancer.
Guan’s group reports a nanorobot with ultrasensitive chemotaxis for precision cancer therapy. After intravenous injection, the nanorobots achieved a 209-fold increase in tumor targeting efficiency compared with conventional passive nanocarriers. When loaded with only 1% of the dose of anticancer drugs, the nanorobots achieved a tumor growth inhibition rate of up to 92.7%. The nanorobots boost the tumor suppression efficacy by approximately 49-fold compared with the passive counterparts.
Cachexia is a metabolic disorder that causes uncontrolled weight loss and muscle wasting in chronic diseases and cancer. A new study by Helmholtz Munich, in collaboration with the Institute of Physiology of the Czech Academy of Sciences in Prague, Heidelberg University Hospital, the German Center for Diabetes Research (DZD), and the German Center for Cardiovascular Research (DZHK), shows that cachexia affects more than just muscles. Numerous organs respond in a coordinated manner, ultimately contributing to muscle loss. Analysis of metabolome and transcriptome data, along with glucose tracing in tumor-bearing mouse models, identified a novel mechanism that plays a key role in cancer-associated weight loss.
UF researchers are uncovering new insights into the complex relationship between the collection of microorganisms that live in the gut — known as the gut microbiota — and our health and immune system.