A Nature Medicine paper by City of Hope and Memorial Sloan Kettering (MSK) Cancer Center outlines a new tool that measures blood inflammation as a marker for poor CAR T therapy outcomes

A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment’s effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH). The findings, published April 1, 2025 in Nature Medicine, offer hope that this therapy could be used to treat a variety of solid tumors, which has so far eluded researchers developing cell-based therapies.

Researchers from Tel Aviv University have developed an innovative method that can help to understand better how cells behave in changing biological environments, such as those found within a cancerous tumor.

Lung cancers with SMARCA4 deficiency are rare, typically showing aggressive behavior and poor prognosis. These tumors rarely harbor common targetable oncogenes like EGFR, ALK, or ROS1. This case report details a nonsmoking middle-aged woman with SMARCA4-deficient non-small cell lung cancer (NSCLC) and rare EGFR mutations who achieved significant tumor response with afatinib.

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise but their efficacy varies, highlighting the need for biomarkers. This study explores TRIM4's role in ovarian cancer's response to CDK4/6 inhibitors, revealing that TRIM4, an E3 ligase, influences sensitivity by modulating hnRNPDL and CDKN2C levels.

Timely follow-up colonoscopies can reduce the mortality rate from colorectal cancer, and patient navigators can play an important role in facilitating screening, according to researchers at the U of A Cancer Center.

Brian Brown, PhD, Director of the Icahn Genomics Institute at the Icahn School of Medicine at Mount Sinai, has been elected to the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE). He was honored for his seminal work in gene therapy and functional genomics, which has helped transform the fields and contributed to key advancements in medicine and biotechnology. Election to the AIMBE College of Fellows is one of the highest professional distinctions in the field. It recognizes the top two percent of experts in medical and biological engineering, and its members are celebrated for their exceptional work in the field. Members are honored for their outstanding contributions to "engineering and medicine research, practice, or education” and to "the pioneering of new and developing fields of technology." Dr. Brown’s election recognizes his groundbreaking work developing innovative technologies that have been broadly used across biomedical fields, including in cancer, immunology, and genetic disease research and therapeutic development.