Many major cancers, including those of the lung, breast and prostate gland, spread to the bones as they progress. These bone metastases are often debilitating, even deadly. They are also notoriously resistant to all kinds of treatment, including immunotherapy.

Exosomes are reshaping how scientists understand cancer progression and immune evasion. This review explores how tumor-derived exosomes orchestrate both pro-tumorigenic signaling and immune modulation within the tumor microenvironment. By highlighting their role in carrying oncogenic RNAs, reprogramming immune cells, and enabling therapy resistance, the authors present exosomes as emerging biomarkers and therapeutic vectors in the evolving landscape of cancer diagnosis and treatment.

Endometrial cancer is a common malignant tumor of the female reproductive system, and its incidence is increasing worldwide. The underlying causes of endometrial cancer are multifactorial. In recent years, the role of diet and lifestyle has received considerable attention and has become a key area of research for cancer prevention. Available literature suggests that different dietary patterns, such as the Mediterranean diet or a plant-based diet, along with moderate physical activity, are associated with a reduced risk of this cancer. Despite these findings, significant gaps in knowledge remain, particularly regarding the specific foods, lifestyle choices, and mechanisms of action that can help mitigate the risk of cancer. Furthermore, the effects of cultural and genetic differences among subpopulations make this issue even more complex. In this context, this review aimed to assess the existing literature on the potential role of diet and lifestyle factors in preventing endometrial cancer, evaluate the available data, and highlight areas that require further investigation to provide concrete evidence and recommendations for prevention.

City of Hope^® Research Spotlight offers a glimpse into groundbreaking scientific and clinical discoveries advancing lifesaving cures for patients with cancer, diabetes and other chronic, life-threatening diseases. Each spotlight features research-related news, such as recognitions, collaborations and the latest research defining the future of medical treatment.

Scientists are using artificial intelligence to enhance and accelerate treatment for glioblastoma, the deadliest brain cancer, with the goal of improving both survival time and quality of life.

Scientists have discovered that licorice extract, a common traditional herb, offers powerful protection against Paraclostridium bifermentans spores—a heat-resistant microbe that threatens the safety and shelf life of ready-to-eat (RTE) chicken breast. In laboratory tests, licorice extract concentrations above 12.5 mg/mL significantly suppressed spore growth, while a 50 mg/mL dose nearly doubled product shelf life at 15 and 20 °C. Predictive modeling confirmed the extract’s impact on microbial growth rates and lag phases. Moreover, treated chicken samples showed slower spoilage, with lower acidity and chemical breakdown. The findings open up new possibilities for natural, plant-based preservation strategies in the meat industry.

Targeted drug delivery to tumors is crucial for effective and safe treatment of cancer. In a recent breakthrough, researchers from Okayama University have developed a pH-responsive nanomaterial using graphene oxide and polyglycerol for cancer drug delivery. The surface of the developed nanomaterial changes its charge in an acidic tumor environment and enables uptake of drugs by cancer cells while avoiding immune clearance. This innovative approach opens doors to precision-driven and more efficient cancer therapies.

Autophagy is a process in which worn out, toxic or degraded cellular components are swept up and recycled to maintain a healthy living cell. When this process is disrupted or disfunctions, it can lead to diseases such as cancer, neurodegeneration, and heart disease.