CNIO researchers create the “human repairome”, a catalogue of DNA “scars” that will help define personalized cancer treatments
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-Nov-2025 03:11 ET (10-Nov-2025 08:11 GMT/UTC)
The human repairome, REPAIRome, will allow researchers around the world to rapidly check out how each of the 20,000 human genes affects DNA repair.
Created by researchers at the Spanish National Cancer Research Centre (CNIO), it is published today in the journal Science.
The human repairome is ‘a powerful resource for the scientific community’, the authors write in Science. It has ‘implications for human health, including cancer treatment’.
It also allows progress ‘towards full control of CRISPR-Cas gene-editing technologies’, they add.
The repairome is ‘a platform for new discoveries,’ says CNIO researcher Felipe Cortés. It has already helped to detect new genetic mechanisms involved in kidney cancer.
Researchers at London Health Sciences Centre Research Institute (LHSCRI) have launched a Phase II clinical trial that aims to treat renal cell carcinoma (kidney cancer) by inserting microscopic beads filled with radiation directly into blood vessels surrounding cancerous tumours. The goal is to improve patient outcomes through a new treatment option.
Three graduate students in CSHL’s dos Santos lab have developed a tool called MaGNet to quickly measure changes in mouse mammary glands. This open-source technology can be used to study how hormonal changes affect mammary glands and may one day allow for earlier breast cancer diagnoses.