Mechanistic insights into VEGF(R) inhibitor-associated arthritis offer promising avenues for developing potential therapeutic strategies to mitigate this treatment side effect and improve the quality of life for cancer patients.

Mitochondria, the “powerhouses of the cell,” are vital cellular organelles that govern energy metabolism, maintain redox homeostasis, synthesize biomacromolecules, and initiate and transmit cell death signals. Besides their diverse physiological functions, research over the recent decades has shown the multifaceted involvement of mitochondria in cancer pathogenesis

Using human cells and cutting-edge technology, the team created a three-dimensional (3D) model that accurately simulates the brain invaded by aggressive cancer. Published in Biofabrication, the study combines frontier science, advanced technology, and international collaboration — while also carrying a personal story: part of the team is formed by a couple of scientists who quite literally bring their work home.

Researchers from EMBL, the University Medical Center Mainz (UMC Mainz), and the Department of Biomedicine (Basel) have uncovered how chronic inflammation reshapes the human bone marrow environment, where blood stem cells reside, long before leukaemia emerges.

In a new study published in Nature Communications, scientists explain how they studied bone marrow samples in individuals with clonal hematopoiesis (CHIP) and myelodysplastic syndrome (MDS), observing how inflammation played a role in a cancerous progression. 

CHIP and MDS patients lose certain healthy stem-cell support cells, which are replaced by inflammatory support cells that become more common as the disease progresses, forming a self-reinforcing inflammatory loop that disrupts normal blood formation.

Overall, the research suggests that inflammatory support cells in the stem cell microenvironment play a key role in damaging the bone marrow early in disease development – potentially offering a new target for treatments that could stop blood disorders from becoming cancerous.

Our body’s “blood factory” consists of specialized tissue made up of bone cells, blood vessels, nerves and other cell types. Now, researchers have succeeded for the first time in recreating this cellular complexity in the laboratory using only human cells. The novel system could reduce the need for animal experiments for many applications.

When aggressive cancer cells spread through the body, they cause metastasis, which significantly reduces a person’s chance of survival. For this spreading to take place, they can switch between different cell states that move with different strategies. In Biomicrofluidics, by AIP Publishing, a team of researchers from the Delft University of Technology and the Kavli Institute of Nanoscience explored the mechanics at play that enable two types of metastatic cancer cells to achieve the same result of movement, with only one doing so via tissue manipulation. The research is among the first to reveal a direct link between cancer cell deformability and active migration through small gaps.