CAR T cells have revolutionized the treatment of certain blood cancers, but they often fail. A new study published in Nature (DOI: 10.1038/s41586-025-09507-9) by scientists at CeMM and the Medical University of Vienna introduces a novel CRISPR screening platform, which discovered unexpected genetic edits that make CAR T cells more effective as cancer therapies

An international team of researchers led by Dr Manel Esteller, head of the Cancer Epigenetics Group at the Josep Carreras Leukaemia Research Institute, has just published the most comprehensive analysis to date of the longest-lived person ever recorded, the Catalan woman Maria Branyas, who passed away at the end of 2024 at the age of 117. The peer-reviewed study, published in the prestigious international journal Cell Reports Medicine, concludes that the biology of supercentenarians is more complex than previously thought, and that the key may lie in a delicate balance between opposing forces.