Risk of developing a subsequent primary cancer varied significantly by age at initial diagnosis, sex, and type of first cancer, according to a study by Oxana Palesh and Susan Hong and colleagues at Virginia Commonwealth University, U.S., published April 28^th in the open-access journal PLOS Medicine.

For many patients with breast cancer, deciding whether cancer has spread to nearby lymph nodes still depends on labor-intensive pathology workflows that require tissue cutting, staining, and expert interpretation. 

Researchers revealed how zinc levels control the endoplasmic reticulum (ER), the cell’s primary protein factory, and how it fundamentally regulates cellular proteostasis. Using fluorescent probes, they found that the transporter ZIP7 keeps zinc levels in the ER low. When ZIP7 is disrupted, zinc level surges, inhibiting the enzyme Ero1 and disrupting the cell’s redox balance. This prevents proteins from folding correctly, leading to an array of pathologies including cancer.