Scientists confirm precursor to commonest form of oesophageal cancer – offering opportunities to catch the disease early
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Jun-2026 21:16 ET (22-Jun-2026 01:16 GMT/UTC)
Scientists have found the strongest evidence to date that a condition known as Barrett’s oesophagus is the starting point for all cases of oesophageal adenocarcinoma – the most common type of oesophageal cancer in the developed world – even when telltale signs of this pre-cancerous stage are no longer visible.
Results of a global, multicentre, phase III clinical trial indicate that datopotamab deruxtecan (Dato-DXd) is effective in improving survival for untreated, advanced triple negative breast cancer (TNBC)
TNBC is an aggressive form of breast cancer, for which the majority of patients with previously untreated advanced disease are largely ineligible for immunotherapy (70%) and face poor prognosisBabies who are exclusively breastfed for at least three months carry markers in their blood that differ from babies who are not breastfed.
The US Food and Drug Administration (FDA) is reviewing a petition to revoke the approval of Roche’s top-selling drug ocrelizumab (Ocrevus) for treating primary progressive multiple sclerosis (PPMS) - a form of MS thought to affect around 15% of patients. The petition alleges that the drug was approved despite internal concerns about a lack of effectiveness in women and a potential increased risk of breast cancer. An investigation published by The BMJ today explores details of the drug’s approval and questions whether ocrelizumab could be doing more harm than good in women with this condition.
In complex diseases, many different genetic changes can push cells into the same harmful state, as is the case with melanoma drug resistance. A new platform, PerturbFate, reveals how diverse genetic perturbations funnel into shared disease states, unlocking targets for new therapies. Next, the team plans to move this approach from cultured cells into living models to study aging and Alzheimer’s.