A study of non-functional pancreatic neuroendocrine tumors (NF-PanNETs) identified an AGR2^high endocrine subcluster enriched in high-grade tumors and showed that simple AGR2 immunohistochemistry serves as a clinically informative prognostic marker. Mechanistically, the transcription factor FOXM1 directly drives the proliferative transcriptional program of AGR2^high cells, while chemical inhibition of FOXM1 showed therapeutic benefit in tumor cells, patient-derived organoids, and xenograft models. Together, the findings provide a new approach for prognostic stratification and identify FOXM1 as a potential therapeutic vulnerability in NF-PanNETs.

How cells respond to the leukemia drug 6-thioguanine still holds surprises: A new study, led jointly by researchers from CeMM and the University of Oxford identifies NUDT5 as an unexpected regulator of drug sensitivity and reveals that its role has nothing to do with its enzymatic activity. Published in Nature Communications (DOI 10.1038/s41467-026-74489-9), the findings combine targeted protein degradation, medicinal chemistry and genetic experiments to uncover a previously hidden layer of thiopurine biology and further challenge traditional views of how enzymes function in cells.

A recent study in the Journal of Nutrition Education and Behavior (JNEB), published by Elsevier, found that how families engage with the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) during the first months after the birth of a child may influence whether they remain enrolled through their child's first year.