A team of scientists at the Garvan Institute of Medical Research has discovered that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment.

Wastewater from aircraft toilets could provide a critical warning system for the global spread of antimicrobial resistant (AMR) superbugs, a silent pandemic that threatens to kill more people than cancer by 2050.

Australian researchers have created the first detailed molecular map of the human bone marrow, revealing new insights that could reshape our thinking about how an incurable blood cancer grows and spreads.

Fucosylation, a crucial post-translational modification, has emerged as a significant factor influencing digestive inflammatory diseases and cancers. This biochemical process, which involves the attachment of fucose to glycoproteins and glycolipids, plays a fundamental role in cell adhesion, signal transduction, and immune response modulation. Understanding the mechanisms of aberrant fucosylation offers a new perspective on the development and progression of conditions affecting the intestine, stomach, liver, and pancreas.

Acute kidney injury (AKI) remains a significant global health challenge, with high mortality rates and the potential for progression to chronic kidney disease. One promising avenue of intervention is targeting mitochondrial biogenesis (MB), a critical cellular process that promotes energy metabolism, stress resistance, and cell survival. By enhancing MB, it may be possible to restore mitochondrial function, alleviate oxidative stress, and improve renal recovery.

This newly published review article offers a comprehensive examination of the complexities of tumor angiogenesis and the origins of endothelial cells (ECs) within tumors. Tumor angiogenesis, a critical process in cancer progression, is characterized by the formation of new blood vessels that sustain tumor growth by supplying oxygen and nutrients. Understanding the diverse sources and mechanisms of endothelial cell development is essential for improving anti-angiogenic therapies, which aim to block blood vessel formation and, consequently, hinder tumor proliferation.