EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 6-Nov-2025 20:11 ET (7-Nov-2025 01:11 GMT/UTC)

How lactate fuels breast cancer—and how to stop it

China Anti-Cancer Association
Peer-Reviewed Publication

A new review reveals how lactate and its derivative lactylation process drive breast cancer progression, opening new therapeutic possibilities.

Journal: Cancer Biology & Medicine

PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures

Science China Press
Peer-Reviewed Publication

A landmark mini-review from Peking Union Medical College Hospital delivers a snapshot of nine PD-1/IL-2 bi-functional drugs now in clinical trials. By silencing PD-1 and selectively fueling T cells with refined IL-2 in one molecule, these agents reinvigorate exhausted immune soldiers while sparing healthy tissue, promising safer and broader cancer cures.

Journal: Science Bulletin

HKUMed identifies key protein in liver cancer resistance and develops inhibitor to enhance therapy and prevent cancer recurrence

The University of Hong Kong
Peer-Reviewed Publication

Researchers from the School of Biomedical Sciences at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), have made a significant advancement that could reshape the treatment landscape for hepatocellular carcinoma (HCC), the most common type of liver cancer, which often resists treatment and recurs. This cancer is especially prevalent in Southeast Asia and China. The research, published in the journal Science Translational Medicine, revealed a previously unknown mechanism that allows HCC to grow more aggressively and evade existing therapies. The team also developed a new small molecule inhibitor that could improve treatment options for HCC patients.

Journal: Science Translational Medicine

Teaching the immune system a new trick could one day level the organ transplant playing field

Medical University of South Carolina
Peer-Reviewed Publication

Transplanted organs are more likely to be rejected by the immune system when there is a mismatch between donor and recipient human leukocyte antigens (HLA). A Medical University of South Carolina team reports in Frontiers in Immunology that it has fitted regulatory T-cells, whose job is to suppress immune responses, with an artificial receptor and other genetic machinery that enable them to target and neutralize B-cells producing antibodies against the mismatched HLA.

Journal: Frontiers in Immunology
Funder: NIH/National Center for Advancing Translational Sciences (NCATS), Human Islet Research Network, Diabetes Research Connection, Medical University of South Carolina, MUSC Hollings Cancer Center

Researchers discover dementia-like behaviour in pre-cancer cells

Cancer Research UK
Peer-Reviewed Publication

Cancer Research UK-funded researchers find dementia-like behaviour in pancreas cells at risk of turning into cancer. The researchers noticed excess “problem protein” molecules forming clumps in these cells, a common feature seen in neurological disease. While early stage, the findings give clues for new ways to study, treat, or potentially prevent pancreatic cancer, a particularly deadly cancer type.

Journal: Developmental Cell
Funder: Cancer Research UK, Wellcome Trust, Medical Research Council, Biotechnology and Biological Sciences Research Council

Leaders at Huntsman Cancer Institute drive theranostics expansion to transform cancer care

Huntsman Cancer Institute
Business Announcement

Huntsman Cancer Institute has appointed experienced leaders to guide its growing research and clinical program in theranostics, a promising new way to find and treat cancer.

Targeting ferroptosis in cancer stem cells: A promising approach to enhance cancer treatment

Compuscript Ltd
Peer-Reviewed Publication

Recent advancements in cancer research are shedding light on a novel therapeutic strategy aimed at overcoming the formidable challenge of cancer stem cells (CSCs). These unique cells are known for their remarkable ability to resist conventional therapies, leading to treatment failures and cancer recurrence. A promising new approach involves targeting ferroptosis, a regulated cell death process driven by iron accumulation and lipid peroxidation, which could significantly improve cancer treatment outcomes.

Journal: Genes & Diseases

Maternal antibodies in breast milk regulate early immune responses in mouse gut

American Association for the Advancement of Science (AAAS)
Peer-Reviewed Publication

The first weeks outside the womb are a massive learning experience for the neonatal immune system, especially in the gut as it learns to distinguish helpful from harmful antigens. In mice, maternal antibodies ingested in breast milk in the first week after birth help to regulate immune responses in the newborn gut, according to a new study by Meera Shenoy and colleagues. This process builds the important partnership between the microbiome and host at an early stage, paving the way for nutrient assimilation, avoiding inappropriate inflammation and resistance against pathogens. Shenoy et al. found that mouse maternal immunoglobin G antibodies bind to bacteria in the neonatal gut to modulate the immune response in the gut mucosa. This antibody-bacteria complex binds to antibody receptors in the gut to limit the response of T cells to food antigens during weaning and in response to experimentally induced colitis during early life. “Translating these findings to human infants will require studies integrating information on the timing of exposure to maternal antibodies, along with the development of key immune components and the intestinal microbiota,” Michael Silverman and Kathryn Knoop write in a related Perspective.

Journal: Science

New tech speeds up AI training for drug discovery/disease research

University of Oregon
Peer-Reviewed Publication

University of Oregon bioengineer Calin Plesa has developed technology that creates massive, high-quality biological datasets at unprecedented speed and scale, solving a critical bottleneck that has prevented AI from tackling biology's biggest challenges—from studying cancer-associated genes to designing new proteins to accelerating drug development.

Journal: Science Advances

A new network could help predict health problems in your pup

PLOS
Peer-Reviewed Publication

A network analysis of more than 26,000 dogs and their health conditions helps reveal which diseases tend to go together, providing data that veterinarians and researchers can use to help treat the problems that dog man’s best friend face, according to a study published DATE in the open-access journal PLOS Computational Biology by Antoinette Fang from the Fred Hutchingson Cancer Center in Seattle, Washington, USA, and colleagues.

Journal: PLOS Computational Biology

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