More than 40% of middle-aged adults with no known heart disease had signs of atherosclerosis, a buildup of fatty deposits that reduce blood flow to the heart, in a study of more than 25,000 adults in Sweden. In more than 5% of the people who had a buildup of fatty deposits, the atherosclerosis narrowed at least one artery by 50% or more. In nearly 2% of the people with artery deposits, the narrowing was so severe that blood flow was obstructed to large portions of the heart.
Physician-scientists want to find a signal that a person with schizophrenia is also headed toward metabolic syndrome, which increases their risk of also developing cardiovascular disease, and which can result from treatment for their brain disorder.
The first randomised phase III clinical trial in stage II melanoma has shown a 35% reduction in the risk of recurrence with adjuvant pembrolizumab compared with placebo. The late breaking results of the KEYNOTE-716 trial are presented at the ESMO Congress 2021.
- Annals of Oncology
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent studies in basic, translational and clinical cancer research from MD Anderson experts. This special edition features oral presentations by MD Anderson researchers at the virtual European Society for Medical Oncology (ESMO) Congress 2021 on novel therapeutic approaches, including cell therapy for solid tumors, antibody drug conjugates targeting TROP2 and neoadjuvant pembrolizumab for advanced solid tumors with mismatch repair deficiencies.
- European Society for Medical Oncology Congress
Bullock helped implement the Domestic Violence Enhanced Perinatal Home Visits (DOVE) program in rural Missouri, which empowered safety planning and reduced domestic violence for hundreds of abused pregnant women. After learning from home health visits that many of the abused women had up to nine different romantic partners during and following pregnancy, Bullock conducted a study to examine the impact of multiple father figures on the cognitive development of the newborn infants. After administering neurodevelopmental tests during home visits three, six and 12 months after birth, she was surprised to find the infants of women who had only one male partner who abused them had worse cognitive outcomes compared to infants of women with multiple male partners, only some of whom were abusive.
- Maternal and Child Health Journal
- National Institutes of Nursing
Plants regulate their growth using hormones, including a group called strigolactones that prevent excessive budding and branching. Strigolactones also help plant roots form symbiotic relationships with microorganisms that allow the plant to absorb nutrients from the soil. These two factors have led to agricultural interest in using strigolactones to control the growth of weeds and root parasites, as well as improving nutrient uptake. These root-extruding compounds also stimulate germination of witchweeds and broomrapes, which can cause entire crops of grain to fail, making thorough research essential prior to commercial development. Now, for the first time, scientists led by UC Riverside have synthesized strigolactones from microbes.
- Science Advances
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A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.
- Journal for ImmunoTherapy of Cancer
- Ministry of Education, Culture, Sports, Science and Technology, ,
A multi-disciplinary team from Lehigh University and the University of Lausanne discovered and characterized a new mechanism that a simple yeast cell uses to acquire its shape. They describe these results in a paper called “Cell patterning by secretion-induced plasma membrane flows” in the latest issue of Science Advances (DOI: 10.1126/sciadv.abg6718).
- Science Advances
PARP inhibitors are an important ovarian cancer treatment, but patients can commonly develop resistance to them. This resistance and how to overcome it are an area of research that Benjamin Bitler, PhD, CU Cancer Center member and assistant professor of reproductive sciences, has pursued with research partners across the CU Anschutz Medical Campus and the country. Now, his ongoing research is supported by a seven-year R37 MERIT Award, given by the National Institutes of Health to provide long-term support to investigators whose research competence and productivity are deemed superior.