A team at Gladstone Institutes has unveiled a powerful computational tool, called CellWalker2, that allows scientists to determine how cell types are related and identify cell groupings that may impact health, leading to a better understanding of the cells they’re studying.

U of A Cancer Center researchers hope to image nerve endings and create objective, quantitative biomarkers for CIPN, leading to better treatment and prevention opportunities.

Radboudumc researchers and international collaborators analyzed cerebrospinal fluid from over 1,000 tuberculous meningitis patients in Vietnam and Indonesia, identifying metabolic markers linked to mortality. They found that ten metabolites, especially hydroxylated fatty acids, predicted poor outcomes regardless of HIV status or disease severity. The findings highlight dysregulated β-oxidation as a key factor in disease progression, pointing to new directions for targeted therapies.

A National Institutes of Health (NIH)-funded study by researchers from Johns Hopkins Medicine, the Johns Hopkins Bloomberg School of Public Health and The Johns Hopkins University Whiting School of Engineering finds that neutrophils — the most abundant type of white blood cells in humans — may be altered by SARS-CoV-2, the virus that causes COVID-19, to cease their normal function of destroying pathogens in the body and, instead, significantly inhibit other immune cells critical for fighting the virus.