Researchers have developed a dynamic approach to improve the deployment of healthcare workers during disease outbreaks. By considering uncertain medical demand, changing healthcare capacity, and infection risks among healthcare staff, the model helps decision-makers allocate medical resources more effectively across regions. The study provides a practical framework for improving healthcare system resilience and supporting timely responses to public health emergencies.

Most plants pack their centromere into a single region of each chromosome, but a few Magnoliales species instead spread centromeric function along the entire chromosome. To understand the genomic basis of this difference, a research team from Northeast Forestry University and BGI Research assembled chromosome-level genomes for the holocentric species Myristica fragrans (nutmeg) and the monocentric species Cananga odorata (ylang-ylang), and compared them using integrated multi-omics analyses. The study was published in Journal of Systematics and Evolution.

A research team has identified three genes that could help prioritize pharmacogenomic testing for older adults in China who receive multiple medications. 

A research team has identified two complementary mechanisms through which huperzine A improves cognition in mice with vascular dementia, linking protection of nerve cells with regulation of a brain circuit involved in cognitive function.

Researchers from Capital Medical University, Beijing, China, have identified a CaN/NFATC3/Id3/E2A/Bmp4 signaling pathway that helps explain how low-intensity pulsed ultrasound (LIPUS) promotes bone regeneration. Id3 was identified as a molecular “brake” that limits LIPUS-induced osteogenesis and was significantly downregulated following ultrasound stimulation. The researchers developed an Id3 inhibitory peptide, rID3, which, when combined with LIPUS, enhanced osteogenesis and bone-defect healing in mice, suggesting a potential strategy for improving ultrasound-based bone regeneration.

A collaborative research team from the University of Electronic Science and Technology of China and the Hangzhou Institute of Medicine of the Chinese Academy of Sciences, proposed a novel self-supervised reconstruction framework that decouples measurement sampling resolution from reconstruction grid density to address the trade-off between sampling and imaging in single-pixel imaging. The framework enables high-pixel-resolution reconstruction from the low-dimensional measurements, providing a new strategy for overcoming resolution limitations in conventional single-pixel imaging.

Even a local mRNA injection can produce unwanted expression in the liver. Researchers have redesigned the lipid nanoparticles that carry mRNA to reduce this spillover in mice while preserving expression in injected muscle. The formulation also supports repeated dosing and improves the confinement of expression after local brain and eye delivery.

Umbilical cord blood is more than a source of stem cells for transplantation. A review in Science China Life Sciences examines how its diverse cells and bioactive components are being explored for cancer immunotherapy, inherited disorders and tissue repair. The authors connect these opportunities with advances in cell expansion, gene engineering and manufacturing, while identifying barriers to clinical translation. They emphasize that many emerging applications still require further evidence of safety, effectiveness and durable benefit.

A recent study published in National Science Review has revealed silicate magma can store far more oxygen than its chemically allows. In high-pressure experiments, silicate melt can store up to about 5 wt.% excess oxygen, which is released as the magma rising. The findings suggest that oxygen-rich magmas could carry oxidizing power from Earth’s interior toward the surface, and may explain links between large-scale magmatism episodes and atmospheric oxidation in Earth’s history.