A new review in Medicine Plus traces a century of deep brain stimulation (DBS), explaining how the therapy alters pathological activity from local circuits to whole-brain networks, and mapping targets and clinical evidence across 16 neurological and psychiatric disorders. It also examines adaptive stimulation, directional leads, and biomarker-guided approaches that could make treatment more precise and personalized.

A new review in Medicine Plus outlines a transformative paradigm for luminal cancers using engineered microbe-based micro/nanorobots. Deployed via oral, suppository, or intracavitary routes, these living platforms bypass physiological barriers, colonize tumor niches, continuously synthesize therapeutics, and remodel the tumor microenvironment. Merging microbial adaptability with synthetic biology, they usher in an era of persistent, spatially controlled intervention.

A new review in Medicine Plus traces the evolution of mRNA lipid nanoparticles (mRNA-LNPs) from prophylactic vaccine vehicles to programmable therapeutic platforms. The authors detail clinical and preclinical progress across infectious disease, cancer, autoimmunity, rare genetic disease and tissue repair, while identifying key translational hurdles including extrahepatic targeting, repeat-dose immunogenicity, off-target editing risks, and scalable manufacturing.

This study analyzes 30 surface-water metagenomes from four functionally distinct waterbody types in Beijing, revealing starkly differentiated antibiotic resistance gene (ARG) landscapes. Urban rivers sustained the highest ARG burden, while relatively isolated urban lakes exhibited the lowest. Notably, receiving waters linked to the South-to-North Water Diversion Project maintained an intermediate load yet displayed the strongest coupling between ARGs and mobile genetic elements (R²=0.965), signaling elevated mobilization potential at these hydrological interfaces. The findings provide a foundational ecological framework for tracking resistance transport and informing risk-oriented management of megacity aquatic networks.

Seventy years after a small group of scientists gathered at Dartmouth College and helped launch artificial intelligence as an academic discipline, AI has evolved from an ambitious idea into a powerful force reshaping science, medicine, industry, and environmental protection.

The BESIII Collaboration, led by the Institute of High Energy Physics of the Chinese Academy of Sciences, has achieved the world's most precise measurement of the electric dipole moment (EDM) of the Lambda (Λ) hyperon using quantum-entangled Λ–anti-Λ pairs produced in J/ψ decays. The result improves the experimental sensitivity by about three orders of magnitude compared with the previous measurement, providing a new way to probe charge-parity (CP) violation in particles containing strange quarks.

A recent study in the Journal of Bioresources and Bioproducts describes a bio-based, multimetallic Fe-MOF nanoreactor designed to enhance chemodynamic and ferroptosis-based cancer therapy. The researchers used protocatechuic acid (PCA), a natural phenolic compound, as a redox-active ligand to construct a mixed-valence Fe-MOF framework. Ultrasmall Au nanoparticles and Cu ions were subsequently introduced to establish an Fe/Cu/Au redox-cycling network, while brazilin was incorporated as a natural therapeutic compound and a 4T1 breast cancer cell membrane was used for biomimetic surface coating. The resulting nanoreactor promoted H₂O₂ conversion, hydroxyl-radical generation and glutathione depletion, while increasing lipid peroxidation and disrupting ferroptosis-defense pathways. In 4T1 tumor-bearing mice, the optimized nanoreactor produced an approximately 80% tumor inhibition rate and also provided T1-weighted MRI contrast, demonstrating the potential of the platform for integrated therapeutic and imaging applications.

With the advancement of long-term crewed deep-space exploration missions, the effects of the microgravity environment on astronauts' brain function have become an important topic in aerospace medicine. The disappearance of the hydrostatic pressure gradient during spaceflight induces cephalad fluid shifts, which can alter cerebral blood flow (CBF) and are closely associated with visual impairment, spatial disorientation, and cognitive decline. However, existing studies have predominantly focused on the steady-state phase during the middle and late stages of microgravity exposure, with insufficient understanding of the characteristics of CBF fluctuations during the early phase of postural transitions. Moreover, as an indicator of terminal perfusion in the cerebral microcirculation, the coupling relationship between CBF and the upstream hemodynamics of the internal carotid and vertebral arteries has not been systematically investigated. In addition, magnetic resonance imaging (MRI) cannot be applied in real time during spaceflight due to its bulky equipment, whereas ultrasound offers the advantages of portability, real-time capability, and radiation-free operation. Therefore, elucidating the association between early macrovascular hemodynamic changes under simulated microgravity and regional CBF alterations, and evaluating the feasibility of using ultrasound parameters as portable predictors of CBF, holds significant scientific importance and application value.

Antimicrobial resistance (AMR) is reshaping the treatment landscape for bacterial infections, and nationwide surveillance is essential for seeing where pressure is easing and where new risks are emerging.