Big Earth Data Journal is calling for papers for a Special Issue on Addressing incomplete reference data for leveraging Artificial Intelligence in Earth Observation applications. This special issue focuses on advancing methodologies for Earth Observation application reference data challenges. It gathers pioneering research, theoretical insights and innovative case studies to boost reference data enhancement, aiming to improve the precision and trustworthiness of AI-driven insights and guide academics, industry professionals and policymakers.This special issue focuses on advancing methodologies for Earth Observation application reference data challenges. It gathers pioneering research, theoretical insights and innovative case studies to boost reference data enhancement, aiming to improve the precision and trustworthiness of AI-driven insights and guide academics, industry professionals and policymakers. Welcome to submit!

Inspired by snake pit organs, we propose a CMOS-integrated upconverter system achieving room-temperature, 4K ultra-high-resolution short-wave and mid-wave infrared imaging. Utilizing colloidal quantum dot barrier heterojunctions and co-hosted emitting units, the device demonstrates superior luminance and upconversion efficiency. This innovation breaks visible light limitations, advancing applications in night vision, agriculture, and industrial inspection.

Wearable/implantable phototherapy devices offer advantages such as portability, ease of use, and personalized treatment. This article focuses on clinical applications, systematically reviewing the mechanisms and applications of phototherapy, as well as the key challenges faced by existing phototherapy devices. It also proposes the integration of AI and flexible sensing technologies to develop closed-loop diagnostic and therapeutic systems.

This study systematically assessed GI cancer risks during working-age period (15–64 years) across 204 countries from 1990 to 2021. Key findings: (1) In 2021, approximately 1 in 46 individuals developed and 1 in 73 died from GI cancers during working age globally; (2) Colorectal cancer showed the highest incidence risk (0.91%), while gastric cancer had the highest mortality risk (0.35%); (3) Males faced approximately twofold higher risks than females, with East Asia and Mongolia exhibiting the highest regional and national risks, and ages 40–64 representing the high-risk period; (4) Despite overall declining trends, colorectal cancer incidence risk continued to rise. These findings provide evidence-based insights for developing targeted screening strategies.

A new review in Chinese Medical Journal details progress in nanocarrier-based cancer therapy. It analyzes polymeric, lipidic, and other nanoplatforms, their roles in immunotherapy, chemotherapy, radiotherapy, and addresses translation challenges like scalability and biosafety.

A new study published in iMetaMed reveals that potassium sorbate, a common food preservative, may cause acute kidney injury by disrupting intercellular communication. Using an integrated approach combining network toxicology, machine learning, and single-cell RNA sequencing, researchers identified the amyloid precursor protein as a central mediator of kidney damage, interacting with immune cells via specific signaling axes.

A new Chinese expert consensus provides critical guidance for using medical imaging to determine whether pancreatic ductal adenocarcinoma (PDAC) can be surgically removed. The consensus, developed by the Group of Abdomen of the Chinese Society of Radiology, emphasizes a multidisciplinary team (MDT) approach and outlines specific imaging techniques for accurate staging. Key recommendations establish contrast-enhanced CT as the primary tool for assessing local tumor spread, while MRI is prioritized for detecting elusive liver metastases. The guidelines also address the limitations of current imaging in evaluating treatment response and highlight the role of diagnostic laparoscopy. This standardized framework aims to improve preoperative planning, personalize treatment strategies, and ultimately enhance patient outcomes across China.