A groundbreaking review by researchers at Central South University highlights six critical signaling pathways—CCNE1/CDK2, MYC/CDK9, CDK4/CDK6/FOXM1, PTEN/PI3K/AKT/mTOR, AURKB, and VEGFA/VEGFR—as promising targets for osteosarcoma (OS) treatment. The study underscores the potential of network-based drug discovery to combat this aggressive bone cancer.

A study by Tianjin First Central Hospital researchers reveals the miR-451/ETV4/MMP13 signaling axis as a critical regulator of NSCLC progression. Findings show miR-451 suppression activates ETV4-MMP13, driving tumor growth and metastasis, offering new therapeutic targets.

A groundbreaking study by researchers at Zhengzhou University reveals a computational framework to identify key inflammatory genes and drug candidates for abdominal aortic aneurysms (AAA). Using single-cell RNA sequencing and molecular docking, the team pinpointed SLC2A3 as a critical target and DB08213 as a promising therapeutic compound.

A study led by researchers at the General Hospital of Western Theater Command reveals that hsa_circ_0000021 promotes cervical cancer (CC) progression by sponging miR-3940-3p and upregulating KPNA2. Findings suggest this circRNA as a potential therapeutic target for CC treatment.

A novel rotating-switch triboelectric nanogenerator (RS-TENG) offers a breakthrough solution to enhance energy harvesting from wind, particularly at low speeds. The RS-TENG increases the instantaneous current by 3.2 times and reduces the response time by 89%, providing a highly promising solution for powering small electronic devices in remote areas with abundant wind resources.