Chronic hepatitis B is difficult to completely eradicate because current antiviral therapies cannot eliminate viral covalently closed circular DNA. Researchers now summarize how combining classical hepatitis B virus markers with emerging biomarkers, including hepatitis B core-related antigen, serum hepatitis B virus RNA, and quantitative anti-hepatitis B core antibody, substantially improves prediction of functional cure. The proposed evidence-based clinical framework could support individualized treatment decisions, optimize monitoring strategies, improve hepatitis B surface antigen clearance, and reduce healthcare costs.

Halide cathode materials are reshaping all-solid-state lithium batteries (ASSLBs) by enabling multi-electron reactions that dramatically boost energy density. A new review traces their evolution from liquid to solid-state systems, spotlighting single-phase electrode designs that eliminate inactive components and the rational design of multi-electron cathode materials. Looking ahead, it highlights AI-driven material discovery and integrated architectures to overcome energy challenges, charting a course toward cheaper, higher-energy ASSLBs.

Shaping electromagnetic waves at will is a long-standing goal in modern science and engineering. Programmable metasurfaces offer a promising route, but existing schemes are often too simple and fixed for real-time, task-oriented, and diverse control. A team from Zhejiang University has now developed a deep-learning-enabled temporal sequencing framework that maps target illusion patterns to modulation sequences, enabling rewritable and customizable electromagnetic illusions in experiments. This work is published in National Science Review.

Three-dimensional (3D) vision is undergoing a profound transformation. Recently, Zhoujie Wu and Qican Zhang from Sichuan University, together with Gunther Notni from the Fraunhofer Institute for Applied Optics and Precision Engineering IOF, published a review paper in Light: Advanced Manufacturing to systematically summarize over four decades of development in fringe projection profilometry (FPP) and reveal a paradigm shift from traditional geometric triangulation toward computational 3D imaging.

A team led by Academician Ge Junbo and Professor Sun Aijun at Fudan University reveals that environmental eustress attenuates doxorubicin-induced cardiotoxicity while enhancing antitumor effects via a hypothalamus-heart-tumor axis. Eustress upregulates hypothalamic BDNF, which activates TrkB receptors on cardiac resident macrophages to inhibit CCL2 secretion, thereby reducing pro-inflammatory Ly6C^high monocyte/macrophage infiltration into heart tissue. In hepatocellular carcinoma models, eustress also downregulates tumor microenvironment CCL2, decreasing immunosuppressive G-MDSCs and M2 macrophages while increasing cytotoxic CD8+ T cells and M1 macrophages. CCL2 is identified as a core dual target for cardio-oncology intervention, providing a safe and accessible non-pharmacological strategy for preventing chemotherapy-related cardiac toxicity in cancer patients.

Eye AI is moving fast, but will it work for people living at high altitude? In a study accepted by Science Bulletin, Dr. Wu Yuan’s team found that leading ophthalmic foundation models can lose accuracy across high-altitude retinal image cohorts. The team developed MIXFound, a lightweight way to combine several models and make AI diagnosis more robust in underrepresented settings.

On-chip photonic systems for generating vectorial optical fields (VOFs) are highly desired, yet conventional devices remain bulky and lack control capabilities. A class of surface-wave-excited complex-amplitude metasurfaces is proposed that can independently control the amplitude, phase, and polarization of locally scattered waves, thereby generating predefined VOFs. The platform significantly expands degrees of freedom in optical field manipulation, paving the way for integrated optics applications such as encrypted holography, augmented reality, super-resolution imaging, and information communication.

For children with early-onset progressive high myopia, the concern is not limited to stronger glasses or longer eyeballs. Over time, high myopia can be associated with structural changes at the back of the eye, including fundus tessellation, choroidal thinning, and myopic maculopathy. These changes may accumulate over many years and increase the risk of future visual impairment. This means that evaluating high myopia interventions should not rely only on refractive error and axial length, but should also consider whether the fundus is undergoing early structural deterioration.  A study published in Eye Discovery provides new evidence from this perspective. Researchers from the Eye & ENT Hospital of Fudan University and the Key Laboratory of Myopia and Related Eye Diseases evaluated three-year changes in refractive status, axial length, and quantitative fundus parameters in children with progressive high myopia who underwent posterior scleral reinforcement (PSR). The procedure used a crosslinked bovine pericardial patch, with the aim of reinforcing the posterior part of the eye and exploring its potential effect on high myopia-related fundus changes.