Lipid‐based nanoplatforms: Revolutionary tools for hepatology from design to clinical challenges
Peer-Reviewed Publication
Updates every hour. Last Updated: 19-Jan-2026 18:11 ET (19-Jan-2026 23:11 GMT/UTC)
In a review article published in MedComm – Biomaterials and Applications, a team of researchers from multiple institutions in China comprehensively explores lipid‐based nanocarriers (LBNCs) as a transformative solution for liver diseases. The review details the rational design of various LBNC types (including liposomes, micelles, nanoemulsions, and more), their preclinical and clinical applications in treating conditions like hepatitis, liver fibrosis, and hepatocellular carcinoma (HCC), as well as the key challenges hindering their translation from laboratory to clinic. It also proposes forward‐looking strategies, such as AI‐driven lipid optimization, to accelerate the clinical adoption of LBNC‐based therapies.
Scientists have developed a novel fluorotellurite glass fiber that dramatically shrinks the size of ultrafast mid-infrared laser systems, a critical tool for science and industry. This new fiber, just centimeters long, replaces meter-long predecessors while offering superior stability and efficiency. The breakthrough paves the way for compact, robust laser sources operating beyond the 4 μm wavelength, opening new possibilities in spectroscopy, environmental sensing, and medical imaging.
Efficiently characterizing the spatial-polarization non-separability of vectorial structured light is of paramount importance across numerous photonic applications. Towards this goal, scientists in China invented a coherent scheme for non-separability measurement, which efficiently detects the non-separability of vectorial structured light through coherent wavefront detection and digital modal decomposition. This work provides new insights for the characterization of vectorial light fields, and may pave the way for many applications based on vectorial structured light.
A recent review article published in Molecular Biomedicine highlights that the clinical development of targeted therapies against the WNT signaling pathway, a key target in cancer treatment, is ushering in new breakthroughs. The review begins with the fundamental mechanisms of Wnt signaling and systematically elaborates on various innovative strategies targeting the WNT pathway, critically assessing their clinical prospects. It emphasizes that by overcoming specificity challenges, developing precise biomarkers, and exploring synergistic effects with therapies such as immunotherapy, targeting the WNT pathway holds the potential to pioneer new paradigms for future precision cancer medicine.
A comprehensive review, published in Molecular Biomedicine, synthesizes recent advancements in single-cell multi-omics technologies pertinent to the study of biliary tract cancers (BTCs). The article underscores the capacity of these potent tools to unveil the substantial heterogeneity inherent in tumors and their microenvironment, thereby paving novel avenues for personalized treatment strategies combating this aggressive cancer.