In the following manuscript, Zahr and Li et al. develop polycation-based polyamidoamine (PAMAM) dendrimers conjugated with an atherosclerotic plaque-homing peptide Lyp1 for the treatment of atherosclerosis.

This study investigates the conversion of endothelial cells to osteoblast-like cells and its role in maintaining bone homeostasis. The authors focus on the Kindlin-2/Piezo1/TGFβ/Runx2 signaling pathway, showing that endothelial-to-osteoblast conversion is crucial for bone health. The findings suggest that endothelial cells can adopt osteoblast-like functions, thus contributing to bone maintenance and repair. This conversion process could have therapeutic implications for bone-related diseases, including osteoporosis and fractures, offering new insights into vascular-bone interactions.